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In recent years, biomass-derived fuels have received increasing attention as one solution to our nation’s continued and growing dependence on imported oil, which exposes the country to the risk of critical disruptions in fuel supply, creates economic and social uncertainties for businesses and individuals, and impacts our national security. The Energy Independence and Security Act of 2007 (EISA) established a mandatory Renewable Fuel Standard (RFS) requiring transportation fuel sold in the U.S. to contain a minimum of 36 billion gallons of renewable fuels, including advanced and cellulosic biofuels and biomass-based diesel, by 2022. While cellulosic ethanol is expected to play a large role in meeting the EISA goals, a number of next generation biofuels show significant promise in helping to achieve the goal. Of these candidates, biofuels derived from algae have the potential to help the U.S. meet the new RFS while at the same time moving the nation ever closer to energy independence. To accelerate the deployment of advanced biofuels, President Obama and Secretary of Energy Steven Chu announced the investment of $800M in new research on biofuels in the American Recovery and Renewal Act. This announcement included funds for the Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy’s (EERE) Biomass Program to invest in the research, development, and deployment of commercial algae-to-biofuel processes. Additional funding is being directed to algae-to-biofuel research both in EERE and other government agencies and programs.