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A drug commonly used to treat arthritis caused a dramatic and rapid improvement in patients with Alzheimer's disease, according to physicians in California. However, scientists and others not involved in the work worry that the report, which was based on trials in a few patients and hasn't been independently confirmed, may offer little more than false hope for Alzheimer's sufferers and their families.

 

 Alzheimer's patients injectied with the anti=inflammatory drug etanercept-marketed as Enbrel-showed dramatic improvements in their functioning within minutes, according to Edward Tobinick, director of the Institute for Neurological Research, a private medical facility in Los Angeles where the patients were treated, and an assistant clinical professor of medicine at th University of California, Los Angeles.

 

"The patients improve literally before your eyes," says Tobinick, who began using etanercept in Alzheimer's patients three years ago. He uses an unconventional method to administer th drug; he injects it near patients' spines. In 2006, he reported success with weekly treatments given to 15 people over the course of six months. In a case study in the latest issue of the Journal of Neuroinflammation, Tobinick and Hyman Gross, who pracitces in Sant Monica, describe how a patient improved within 10 menutes of treatment, and how cogintive tests performed two hours after the treatment showed a marked improvement over tests given before the injection. Tobinick says that the rapid improvement is typical in patients he has injected with etanercept. He treats them weekly, or, in some cases, less often.

 

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