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The Future of the Human Genome

  • 등록일2011-02-11
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The Future of the Human Genome


What will the next 20 years of research bring? Eric Green, director of the National Human Genome Research Institute, discusses the institute's vision.

 

 


In 2003, just two years after the official publication of the human genome draft, the National Human Genome Research Institute (NHGRI) outlined its plans for studying this promising new scientific resource. Nearly 1,000 sequenced genomes later, the institute has drawn out a new vision, published today in the journal Nature, for exploring the human genome.  

 

Eric Green, NHGRI's director, says this plan is much more specific than the one that came before. It lays out specific domains of research activity, including understanding the genome, how it works, and how we can use this knowledge to further the science and practice of medicine. Green talks with TR about what he hopes to see happen in the next few decades and the major hurdles to getting there.

 

 

TR: It's been a decade since the publication of the human genome. What can we expect to see over the next 10 years?

 

Green: The timetable is still wide open, but we can imagine that we will start to see spectacular advances in our understanding of how the genome works, how disease works, and how genomic changes are associated with disease. But truly changing medicine will take more than 10 years.

 

 

What do you mean by how the genome works?

 

What is the functional wiring of genome? We know all the genes, for the most part. But we have barely scratched the surface in understanding the two-thirds of elements that aren't genes. We need to catalog them and understand their choreography. How does variation in these elements play a role in disease? Evidence continues to suggest that the majority of variants associated with common diseases are in noncoding regions of DNA, so understanding how they actually confer risk for disease will be critically important

 

 

.....(계속)

 

 

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