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Leap forward in structural biology will revolutionise drug making
분류 기술동향 > 생명과학 > 구조생물학
출처 Medical Research Council 조회 3649
자료발간일 2008-06-25 등록일 2008-07-07
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내용바로가기 http://www.mrc.ac.uk/Newspublications/News/MRC004651
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Leap forward in structural biology will revolutionise drug making

 
 
A new method for determining the detailed architecture of key drug targets that relay vital messages into our cells could revolutionise the way we make and test drugs.

For decades it has been difficult to obtain information about the structure of proteins on the surface of cells that many drugs are designed to latch on to.

However, a new approach, developed by scientists at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, can reveal the precise structures of recombinant G protein-coupled receptors (GPCRs), proteins that cross the cell membrane and are important targets for drug development.

This novel method will allow scientists developing drugs to compare the structure of highly similar drug receptor proteins, called receptor subtypes, and produce more selective drugs. It is thought the findings, published in Nature, could also apply to many other key proteins associated with cell membranes, which mediate other important physiological processes.
 
 
 
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Leap forward in structural biology will revolutionise drug making 2008-07-07