홈 > BT동향 > 기술동향
|Leap forward in structural biology will revolutionise drug making|
Leap forward in structural biology will revolutionise drug making
A new method for determining the detailed architecture of key drug targets that relay vital messages into our cells could revolutionise the way we make and test drugs.
For decades it has been difficult to obtain information about the structure of proteins on the surface of cells that many drugs are designed to latch on to.
However, a new approach, developed by scientists at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, can reveal the precise structures of recombinant G protein-coupled receptors (GPCRs), proteins that cross the cell membrane and are important targets for drug development.
This novel method will allow scientists developing drugs to compare the structure of highly similar drug receptor proteins, called receptor subtypes, and produce more selective drugs. It is thought the findings, published in Nature, could also apply to many other key proteins associated with cell membranes, which mediate other important physiological processes.
☞ 자세한 내용은 첨부파일을 참고하시기 바랍니다.
친구에게 이 자료를 추천하기
|[국내외 연구실소개] Laboratory of Structural Biology||2012-12-10|
|Structural Biology Underpins R&D Efforts||2010-10-07|
|Leap forward in structural biology will revolutionise drug making||2008-07-07|