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Systems biotechnology for strain improvement
분류 기술동향 > 생명과학 > 시스템생물학
출처 http://www.sciencedirect.com 조회 1757
자료발간일 2005-06-20 등록일 2005-06-20
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Systems biotechnology for strain improvement 



Various high-throughput experimental techniques are routinely used for generating large amounts of omics data. In parallel, in silico modelling and simulation approaches are being developed for quantitatively analyzing cellular metabolism at the systems level. Thus informative high-throughput analysis and predictive computational modelling or simulation can be combined to generate new knowledge through iterative modification of an in silico model and experimental design. On the basis of such global cellular information we can design cells that have improved metabolic properties for industrial applications. This article highlights the recent developments in these systems approaches, which we call systems biotechnology, and discusses future prospects...
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Introduction
 
High-throughput x-omic analyses for strain improvement
   Genome analysis
   Tranome analysis
   Proteome analysis
   Metabolome and fluxome analysis
   Combined omics analysis

In silico modelling and simulation
   Construction of an in silico model
   In silico metabolic simulation
 
Systemic and integrative strategy for developing improved strains

Future prospects

Acknowledgements

Glossary

References
 
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Systems biotechnology for strain improvement 2005-06-20