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행사/교육

Drug Metabolism - Solving Knowledge Gaps in Drug Metabolism and Pharmacokinetic Prediction, Improving Translational Medicine

  • 등록일2015-07-06
  • 조회수4408
  • 구분 국외
  • 행사교육분류 행사
  • 주관기관
    Gordon Research Conference
  • 행사장소
    Holderness School Holderness, NH
  • 행사기간
    2015-07-12 ~ 2015-07-17
  • 원문링크
  • 첨부파일

 

Application Deadline

This meeting is currently oversubscribed (full). You may still an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Deion

2015 will mark the 45th year of the Gordon Research Conference on Drug Metabolism. Scientists from industry, academia and regulatory institutions, graduate students and post-doctoral fellows have gathered for the past four decades at this venue to present and discuss cutting-edge drug metabolism science. This long tradition has endeared this conference as one of the perennial favorites in the drug metabolism community. Next year’s conference will on key knowledge gaps and improvements in preclinical to clinical translation, ranging from in vitro studies and mechanistic approaches to mathematical modeling, and more broadly how to best combine these tools. Each scientific presentation will include unpublished data. The conference structure will follow an "exploded view", from looking at translational medicine as a whole, to zooming in to specific areas of intense research efforts, where knowledge is rapidly advancing. Topics will include physiologically-based pharmacokinetic (PBPK) modeling as a predictive tool, the impact of pharmacogenomics and disease state, oxidative and conjugative metabolism, drug transporters, biologics, and revolutionary new and emerging technologies. Attendees are encouraged to posters: Vice Chair Kim Brouwer will organize the poster sessions. The Wednesday evening program will feature a mix of six graduate students and post-doctoral fellows, who will deliver oral presentations to be ed from the posters. The collegial nature of the conference offers a wonderful opportunity to learn and discuss unpublished research, share new ideas, and establish new collaborations.

With the afternoons free, attendees are encouraged to enjoy the many outdoor recreational activities in the New Hampshire area. We will maintain this conference’s afternoon traditions, including Monday tennis, Tuesday Academia vs. Industry softball game (no experience necessary!), and Wednesday golfing. Lastly, there are always hiking and canoeing outings in the White Mountains. The registration fee includes housing on the wonderful campus of Holderness School and all meals.

Meeting Program

Sunday
2:00 pm - 9:00 pm Arrival and Check-in
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Keynote Session: Improving Drug Properties Through Mechanistic Modeling of Drug Disposition
Discussion Leader: Michael Zientek (Pfizer, USA)
7:40 pm - 7:55 pm Opening Remarks
7:55 pm - 9:00 pm Stephen Hall (Eli Lilly and Company, USA)
"Improving Drug Properties Through Mechanistic Modeling of Drug Disposition"
9:00 pm - 9:30 pm Discussion
Monday
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm PK Prediction: From Test Tube to Human
Discussion Leader: Karen Rowland-Yeo (SimCYP / Certara, USA)
9:00 am - 9:05 am Introduction by Discussion Leader
9:05 am - 9:35 am Christopher Gibson (Merck, USA)
"IVIVE of UGT Data - Between Lot Variability in UGT Relative Activity Factor"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 am Hannah Jones (Pfizer, USA)
"Utility of PBPK Modelling and IVIVC Scaling Factors for the Prediction of Clinical PK for OATP Substrates"
10:20 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:30 am Karen Rowland-Yeo (SimCYP / Certara, USA)
"Application of PBPK Modeling in an Oncology Setting ? Complex DDIs and Disease Interactions"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Steven Leeder (Children's Mercy Hospital, USA)
"Pediatric PBPK Models: Shifting the Focus from Populations to Individuals"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Personalized Medicine: Pharmacogenomics and Disease States on Prediction of Drug Disposition
Discussion Leader: Erica Woodahl (University of Montana, USA)
7:30 pm - 7:35 pm Introduction by Discussion Leader
7:35 pm - 8:05 pm Steven Scherer (Human Genome Sequencing Center, USA)
"Characterizing Difficult Drug Metabolism Gene Targets"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Rachel Tyndale (University of Toronto, Canada)
"Pharmacogenetic Variation in CYPs Alters Smoking, Tobacco-Related Diseases, and Smoking Treatment"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Erica Woodahl (University of Montana, USA)
"Pharmacogenomics with American Indian Populations: Unique Cytochrome P450 Variation"
9:25 pm - 9:30 pm Discussion
Tuesday
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Oxidative Metabolism: The Advances and Challenges of In Silico, In Vitro and Prediction Sciences
Discussion Leader: Jane Kenny (Genentech, USA)
9:00 am - 9:05 am Introduction by Discussion Leader
9:05 am - 9:35 am Gabriele Cruciani (University of Perugia, Italy)
"Predicting Metabolic Biotransformations, Fact or Fantasy?"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 am Bill Smith (Gilead Sciences, USA)
"Dealing with Those 'Other' Drug Metabolizing Enzymes: In Vitro and In Vivo Challenges"
10:20 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:30 am Cyrus Khojasteh (Genentech, USA)
"Understanding Mechanisms of Oxidation: Tools, Enzymes, and Electron Pushing"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Nina Isoherranen (University of Washington, USA)
"Oxidative Metabolism During Pregnancy and in Infants: Maternal-Fetal Continuum in Drug and Vitamin Disposition"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Advances in Conjugative Metabolism: From Molecules to Populations
Discussion Leader: Michael Coughtrie (University of British Columbia, Canada)
7:30 pm - 7:35 pm Introduction by Discussion Leader
7:35 pm - 8:05 pm Chantal Guillemette (Laval University, Canada)
"Splice Variants ? Novel Regulators of UGT Function"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Catherijne Knibbe (St. Antonius Hospital / LACDR, Leiden University, The Netherlands)
"Predicting Drug Conjugation in Special Populations"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Thomas Leyh (Albert Einstein College of Medicine, USA)
"Human Sulfotransferases - What They Do, and How They Do It"
9:25 pm - 9:30 pm Discussion
Wednesday
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Understanding and Predicting the Metabolism and Pharmacokinetics of Biologics
Discussion Leader: Dhavalkumar Shah (State University of New York at Buffalo, USA)
9:00 am - 9:05 am Introduction by Discussion Leader
9:05 am - 9:35 am E. Sally Ward (Texas A&M Health Science Center, USA)
"Subcellular Trafficking and Metabolism of Biologics"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 am Eric Ezan (Program Technologies for Health (PTTS), France)
"Assessment of the Metabolism of Therapeutic Proteins and Antibodies"
10:20 am - 10:35 am Discussion
10:35 am - 11:05 am Coffee Break
11:05 am - 11:35 am Dhavalkumar Shah (State University of New York at Buffalo, USA)
"Platform PBPK Model for Biologics and Its Evolution Towards Pediatric Population"
11:35 am - 11:45 am Discussion
11:45 am - 12:15 pm Honghui Zhou (Johnson & Johnson, USA)
"Drug-Drug Interactions for Therapeutic Biologics"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm Young Investigator Presentations
Discussion Leader: Henry Strobel (University of Texas Medical School at Houston, USA)
7:30 pm - 7:40 pm Introduction by Discussion Leader
7:40 pm - 7:50 pm Alenka Jaklic (University of Washington, USA)
"Development of a Human Renal Proximal Tubule Microphysiological System for the Assessment of Drug Transport"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:05 pm Zoe Riches (University of British Columbia, Canada)
"Pediatric Toxicity of Lamotrigine Through Inadequate Glucuronidation: An IVIVE and PBPK Modeling Approach to Rational Drug Dosing in Children"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:20 pm Sreeja Sarasamma (Rajiv Gandhi Centre for Biotechnology, India)
"Impact of CYP3A5 Polymorphism on Tacrolimus to Predict the Optimal Initial Dose Requirements in South Indian Renal Transplant Recipients"
8:20 pm - 8:25 pm Discussion
8:25 pm - 8:35 pm Ryota Shizu (National Institute of Environmental Health Sciences, NIH, USA)
"Inactive CAR Is a Homodimer that Dissociates for Activation"
8:35 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm Isha Taneja (CSIR, Central Drug Research Institute (CDRI), India)
"Metabolic Profiling, Metabolite Identification and CYP Inhibitory Potential of Medicarpin, a Potential Anti-Osteoporotic Agent, Using In Vitro Rat and Human Test Systems"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:05 pm Chunxue Wang (Vanderbilty University, USA)
"Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:30 pm General Discussion
Thursday
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Transporter Sciences: Evolving to a New Realm of Understanding Drug Interactions from a Victim Perspective
Discussion Leader: Caroline Lee (Ardea Biosciences, USA)
9:00 am - 9:05 am Introduction by Discussion Leader
9:05 am - 9:35 am Harma Ellens (GlaxoSmithKline Pharmaceuticals, USA)
"Digoxin DDI and Appropriate In Vitro Models to Accommodate Uptake Kinetics"
9:35 am - 9:50 am Discussion
9:50 am - 10:20 am Katherine Fenner (AstraZeneca, United Kingdom)
"Overlap in Drug-Drug Interactions Mediated via Influx, Efflux and Metabolism"
10:20 am - 10:35 am Discussion
10:35 am - 11:00 am Coffee Break
11:00 am - 11:30 am Mitchell Taub (Boehringer Ingelheim Pharmaceuticals, Inc., USA)
"Probe Drug Cocktail for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Maciej Zamek-Gliszczynski (GlaxoSmithKline Pharmaceuticals, USA)
"What Is the Optimal Metformin Clinical DDI Study Design that Enables a PD-Based Dose Adjustment Decision?"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Role of Proteomics and Mass Spectrometry in Drug Metabolism and Pharmacokinetic Prediction
Discussion Leader: Deepak Dalvie (Pfizer, USA)
7:30 pm - 7:35 pm Introduction by Discussion Leader
7:35 pm - 8:05 pm Philip Smith (University of North Carolina at Chapel Hill, USA)
"Quantitating Drug Metabolizing Enzymes and Transporters by Using Stable Isotope-Labeled Peptide Standards and Liquid Chromatography-Tandem Mass Spectrometry"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Stephen Castellino (GlaxoSmithKline Pharmaceuticals, USA)
"MALDI Imaging MS: Snapshots of Drug Disposition in Tissues"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:25 pm Paul Hollenberg (University of Michigan, USA)
"Mechanism-Based Inactivators of Cytochromes P450 as Probes of Structure and Function"
9:25 pm - 9:30 pm Discussion
Friday
7:30 am - 8:30 am Breakfast
9:00 am Departure