산업동향
Challenges For Biomedical Informatics And Pharmacogenomics
- 등록일2003-04-23
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- 분류산업동향 > 제품 > 바이오의약
030423w.pdf
CHALLENGES FOR BIOMEDICAL INFORMATICS
AND PHARMACOGENOMICS
Russ B. Altman and Teri E. Klein
Stanford Medical Informatics, Stanford, California 94305-5479;
e-mail: russ.altman@stanford.edu, teri.klein@stanford.edu
Key Words bioinformatics, pharmacogenetics, computation, databases
■ Abstract Pharmacogenomics requires the integration and analysis of genomic, molecular, cellular, and clinical data, and it thus offers a remarkable set of challenges to biomedical informatics. These include infrastructural challenges such as the creation of data models and databases for storing these data, the integration of these data with external databases, the extraction of information from natural language text, and the protection of databases with sensitive information. There are also scientific challenges in creating tools to support gene expression analysis, three-dimensional structural analysis, and comparative genomic analysis. In this review, we summarize the current uses of informatics within pharmacogenomics and show how the technical challenges that remain for biomedical informatics are typical of those that will be confronted in the postgenomic era.
WHAT IS BIOMEDICAL INFORMATICS?
Biomedical informatics is the study of information flow within biology and medicine. The use of computational techniques in biomedical research dates back to the first general purpose computers but interest in the techniques has exploded in the last decade (1). The increased interest stems from the availability of experimental techniques that create data that simply cannot be manually analyzed and require computational intervention. Many areas of biology and medicine are being revolutionized by the introduction of new experimental techniques, accompanied by informatics methodologies that fundamentally the way that investigators do their work.
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