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The President’s 2013 Budget provides nearly $1.8 billion for the National Nanotechnology Initiative (NNI), a sustained investment in support of the President’s priorities and innovation strategy. Cumulatively totaling almost $18 billion since the inception of the NNI in 2001 (including the 2013 request), this support reflects nanotechnology’s potential to significantly improve our fundamental understanding and control of matter at the nanoscale and to translate that knowledge into solutions for critical national issues. NNI research efforts are guided by two strategic documents developed by the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the National Science and Technology Council (NSTC), the 2011 NNI Strategic Plan (nano.gov/node/581) and the 2011 NNI Environmental, Health, and Safety Research Strategy (nano.gov/node/681).