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A. Foreword................ 5
John Marks and Bertil Andersson, ESF
 

B. Executive Summary................  6
Roel van Driel, University of Amsterdam and Netherlands Institute for Systems Biology, Amsterdam,
The Netherlands and Hans Westerhoff, Manchester Centre for Integrative Systems Biology, UK
 

C. Systems Biology: scientific views about what, why and how............  8
 

1. Systems Biology: definitions and perspectives................  8
Lilia Alberghina, Department of Biotechnology & Biosciences, University of Milano-Bicocca, Milan, Italy

2. Marrying diverse partners ? a mixed complementary approach for integrating bottom-up
and top-down methods in Systems Biology................  9
Matthias Reuss, Institute of Biochemical Engineering and Centre Systems Biology, University of Stuttgart, Germany
 

 

3. Systems Biology calls for coordinated large-scale international efforts to meet Grand
Challenges in life sciences................  12
Roel van Driel, Netherlands Institute for Systems Biology and University of Amsterdam,
Amsterdam, The Netherlands

 

4. Systems Biology and the bioengineering of living organisms................  15
Uwe Sauer, Institute of Molecular Systems Biology, ETH, Zurich, Switzerland
 

 

5. Does modelling of complex biological systems require new types of mathematics?................  16
Mats Gyllenberg, Department of Mathematics and Statistics, University of Helsinki, Finland

 

6. Engineering approaches: what can we learn from it in Systems Biology?............ 19
Olaf Wolkenhauer, University of Rostock, Germany
 

 

7. The role of information technology for Systems Biology................  21
Heikki Mannila, Helsinki Institute for Information Technology (HIIT), Helsinki University
of Technology & University of Helsinki, Finland

 

8. The need for standardisation in Systems Biology ................ 23
Ursula Klingmuller, Marcel Schilling, Sebastian Bohl and Andrea C. Pfeifer, Group
‘Systems Biology of Signal Transduction’, DKFZ, Heidelberg, Germany
 

 

9. Role of national and international funding organisations in Systems Biology ................ 27
Alfred Game, BBSRC, Swindon, UK; Christina Kyriakopoulou, Fred Markus
& Jacques Remacle, EC DG Research, Brussels, Belgium

 

10. Opportunities and challenges for Systems Biology in drug discovery and development ................ 29
Adriano Henney, AstraZeneca, Global Discovery Enabling Capabilities & Sciences, Cheshire, UK
 

 

11. The importance of Systems Biology for the food industry ? Systems Biology at Unilever................  31
Janette Jones, Port Sunlight Laboratory, UK; Guy Warner, SEAC Colworth Park, UK;
Bernd van Buuren, Vlaardingen Laboratory, The Netherlands; & Frans van der Ouderaa,
Corporate Research, Colworth Park, UK

 

12. Systems Biology for profit in SMEs................  32
John Savin, Wendover Technology, Wendover, UK

 

 

D. Recommendations and Priority Areas................  37

 

1. Recommendations to meet the Grand Challenge................  37

2. Priority areas in Systems Biology for the next five and 10 years................  38
 

 

 

1. Activities................  41
 

2. Committees and Scientific Advisory Board................  41

3. Workshop Participants ................ 42
 

4. Participants of the Gosau Conference (17-18 March 2005, Gosau, Austria)...........  42

 

 

ESF Policy Briefing No. 25 ‘Systems Biology: a Grand Challenge for Europe’............. 45
 

 

 

1. Selected reviews on Systems Biology published in 2006................  51
 

2. Selected books................  51

3. Congresses and workshops ................ 52
? 2006
? 2007
? 2008
 

4. Examples of National, European and International Initiatives................  53

5. Selected Systems Biology Institutes ................ 54
 

6. Systems Biology Organisation................  54

7. World Technology Evaluation Center (WTEC) Inventory................  54