행사/교육
Metabolism and Cardiovascular Risk
- 등록일2008-07-31
- 조회수2213
- 구분 국외
- 행사교육분류 행사
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주관기관
Keystone Symposia on Molecular and Cellular Biology
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행사장소
Breckenridge, Colorado
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행사기간
2008-09-23 ~ 2008-09-28
- 원문링크
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첨부파일
Metabolism and Cardiovascular Risk
Organizers: E. Dale Abel, Ira J. Goldberg and Karin E. Bornfeldt Cardiovascular disease is the major cause of mortality in developed countries and emerging economies worldwide. Important risk factors include diabetes, obesity and dyslipidemia. Given the growing world
wide epidemic of obesity and the metabolic syndrome there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. Major
problems in the field include: translating observations regarding the role of disordered lipid metabolism, inflammation and oxidative stress into meaningful therapies; determining if reduction in insulin resistance will reverse the increase in risk; and translating new genetic data into robust models for predicting risk.
The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into
the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.
wide epidemic of obesity and the metabolic syndrome there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. Major
problems in the field include: translating observations regarding the role of disordered lipid metabolism, inflammation and oxidative stress into meaningful therapies; determining if reduction in insulin resistance will reverse the increase in risk; and translating new genetic data into robust models for predicting risk.
The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into
the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.