바이오인

 

 

Bioinorganic chemistry covers a broad range of topics including, but not limited to, model complexes that mimic how a protein activates a substrate, studying how a particular organism deals with metal stress or deficiency, and biological sensors that utilize metal ions. The overlying theme, though, is the importance of metals and metal-ligand interactions in a biological context.

 

The Gordon Graduate Research Seminar in Bioinorganic Chemistry (GRS) was developed in 1996 in response to the consistent oversubscription of its “parent” meeting, the Gordon Research Conference on Metals in Biology (MIB). The two conferences overlap for one session with the GRS providing the concluding poster session for MIB. This is an excellent opportunity for young researchers to interact with leading principal investigators in the field.

This conference series has gained significant international recognition, attracting students from around the world. Given the multifaceted scope of this field, scientists new to this field of study are particularly benefited by interaction with researchers in other disciplines. We invite and encourage students from any sub-discipline in Bioinorganic Chemistry to submit abstracts for poster or oral presentations. To be considered for an oral presentation for this meeting, please submit your application by November 1, 2008.

 

For those interested in attending, there will be two optional panel discussions at the conference. They are listed below:

 

Beyond the PhD: Getting and Succeeding in Your Postdoc
Beyond the PhD: Getting and Succeeding in Your First Academic Position

 

 

 

 

 

THURSDAY

4:00 pm - 9:00 pm Arrival and Check-in
6:00 pm Dinner
7:30 pm - 8:45 pm  JOINT SESSION WITH "METALS IN BIOLOGY"
                              Discussion Leader: David M. Dooley (Montana State University)
7:40 pm - 8:30 pm William B. Tolman (University of Minnesota)
                             "Biomimetic Activation of O2 and N2O by Copper"
8:30 pm - 8:45 pm  Discussion
8:45 pm  Joint Poster Session (presented by the GRS: Bioinorganic Chemistry)

 

FRIDAY

 

7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm  METALS IN INFECTION AND IMMUNOLOGY
                                Discussion Leader: Eric P. Skaar (Vanderbilt University)
9:15 am - 9:45 am Sandhya Muralidharan (Wayne State University)
                             "The N-terminal domain of ZntA: its function as a metal chaperone to the

                             transporter"
9:45 am - 9:50 am  Discussion
9:50 am - 10:20 am Claire J Parker Siburt (Duke University)
                               "Hijacking Transferrin-bound Iron: Iron Transport from outside the cell to

                                the periplasm of pathogenic Neisseria gonorrhoeae"
10:20 am - 10:25 am  Discussion
10:30 am - 10:45 am  Coffee Break
10:45 am - 11:15 am Christine M. Phillips (M.I.T.)
                                "Metal preference at the second metal binding site of E. coli NikR"
11:15 am - 11:20 am  Discussion
11:20 am - 11:50 am Nesha O. Andoy (Cornell University)
                                "Single Molecule Study of Metalloregulator-DNA Interactions"
11:50 am - 11:55 am  Discussion
11:55 am - 12:25 pm  Maura O’Neill (University of Maryland)
                                 "Cytoplasmic Bingding Protein PhuS is Essential for Heme Homeostasis 

                                  in Pseudomonas aeruginosa"
12:25 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm  SPECTROSCOPY OF METALS IN BIOLOGY
                              Discussion Leader: David L. Tierney (University of New Mexico)
7:45 pm - 8:15 pm Caleb B. Bell (Stanford University)
                             "Spectroscopic elucidation of factors that tune binuclear non-heme iron

                              active sites for diverse oxygen reactivity"
8:15 pm - 8:20 pm  Discussion
8:20 pm - 8:50 pm Sarah Bowman (University of Rochester)
                             "Insight into how the His-Fe(III) interaction in heme proteins modulates       

                              reactiity"
8:50 pm - 8:55 pm  Discussion
8:55 pm - 9:25 pm  Katherine M. Van Heuvelen (University of Wisconsin-Madison)
                             "Insights into the Mechanism of Methyl-Coenzyme M Reductase:

                             Spectroscopic and Computational Studies of Ni-C Bonding in Cofactor 

                             F430"
9:25 pm - 9:30 pm  Discussion
9:30 pm  Poster Session

 

7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm  METALLOPROTEINS: FROM FUNCTION TO DE NOVO DESIGN
                                Discussion Leader: Catherine L. Drennan (M.I.T.)
9:15 am - 9:45 am Jeremy D. Cook (Wayne State University)
                             "Identifying the Functional Details of Frataxin’s Contribution During Fe-S 

                              Cluster Bioassembly"
9:45 am - 9:50 am  Discussion
9:50 am - 10:20 am Seung Jae Lee (University of Maryland)
                               "How does Iron Binding affect the function of Zinc Finger Proteins?"
10:20 am - 10:25 am  Discussion
10:30 am - 10:45 am  Coffee Break
10:45 am - 11:15 am Eric N. Salgado (University of California, San Diego)
                                "Symmetry of Metal-induced Protein Assemblies Dictated by Metal  

                                 Coordination Geometry Preferences"
11:15 am - 11:20 am  Discussion
11:20 am - 11:50 am Jolene V. Schuster (Dartmouth University)
                                 "Investigation of Cu(I) Binding Thermodynamics of Cellular Proteins Ctr1,

                                  Hah1 and ATP7B"
11:50 am - 11:55 am  Discussion
11:55 am - 12:25 pm Bennett R. Streit (University of Notre Dame)
                                "Mechanistic and structure-activity study of the O-O bond forming, 

                                  heme-dependent enzyme, chlorite dismutase"
12:25 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
                             (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; 

                             Discuss future Site & Scheduling preferences; Election of the next Vice

                              Chair)
7:30 pm - 9:30 pm  BIOINORGANIC MATERIALS IN SENSING AND IMAGING
                              Discussion Leader: Christopher J. Chang (University of California,

                               Berkeley)
7:45 pm - 8:15 pm Kenia A. Parga (University of Puerto Rico - Rio Piedras Campus)

                             "Synthesis of Fe8-Based MRI Contrast Agents Targeted to Ovarian Cancer

                              Cells"
8:15 pm - 8:20 pm  Discussion
8:20 pm - 8:50 pm Jan L. Vinkenborg (Eindhoven University)
                              "Intracellular zinc imaging using FRET-based sensor proteins"
8:50 pm - 8:55 pm  Discussion
8:55 pm - 9:25 pm Philip J. Dittmer (University of Colorado, Boulder)
                            "Genetically encoded FRET based sensors to elucidate spatial distribution 

                             of cellular zinc"
9:25 pm - 9:30 pm  Discussion
9:30 pm  Poster Session

 

7:30 am - 8:30 am Breakfast
9:00 am - 11:00 am  DNA, RNA AND METALS
                                Discussion Leader: Jacqueline K. Barton (Cal. Tech.)
9:15 am - 9:45 am  Brian Zeglis (Cal. Tech.)
9:45 am - 9:50 am  Discussion
9:50 am - 10:20 am  Nandini Nagraj (University of Illinois at Urbana-Champaign)
                                "Probing metal binding of the 8-17 DNAzyme using biophysical and 

                                 biochemical methods"
10:20 am - 10:25 am  Discussion
10:25 am - 10:55 pm Samuel Pazicni (University of Michigan)
                                "Identification and characterization of a tightly bound metal in the P4 helix 

                                 of the metallo-ribozyme ribonuclease P"
10:55 am - 11:00 am  Discussion
11:00 am - 11:10 am  Coffee Break
11:10 am - 12:30 pm  ENVIRONMENTAL BIOINORGANIC CHEMISTRY 
                                 Discussion Leader: Rachel N. Austin (Bates College)
11:20 am - 11:50 pm Cheryl Saunders (Dalhousie University)
                                "Synthesis and Characterization of Lead-Amino Acid and Mercury-Amino

                                 Acid Complexes"
11:50 am - 11:55 am  Discussion
11:55 am - 12:25 pm  Kathy Batchler (Yale University)
                                 "Siderophore Scavenging of Titanium"
12:25 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm Departure