바이오인

 

 

 

The recent discoveries of the RNAi pathway in mammalian cells and the finding that oligonucleotides can activate the innate immune system through Toll-like receptors have resulted in increased interest in oligonucleotide-based therapeutics. There are two basic therapeutic approaches in which oligonucleotides are being utilized: (1) binding to RNA resulting in selective inhibition of gene expression; and (2) modulating protein function by direct binding to proteins. Although both approaches share common manufacturing, toxicology and ADME issues, oligonucleotides that are designed to bind RNA inside the cell have a fundamental different set of challenges than oligonucleotides designed to bind to proteins outside the cell. This meeting will focus on the former application. A goal of this meeting is to bring together scientists from both the basic science disciplines and applied disciplines to gain a common understanding of the attributes and challenges the technology faces. This meeting will consider basic mechanisms by which oligonucleotides can be exploited to modulate gene expression, mechanisms for distribution of oligonucleotides to tissues and within cells and how chemistry and/or formulations can improve the pharmaceutical properties of oligonucleotides. Finally recent advances in both preclinical applications and clinical results will be presented.

 

 

Sunday, February 8
3:00 - 7:30 PM  Registration                                                                      Alpine Gallery 
6:30 - 7:30 PM  Refreshments                                                                    Heritage Hall 
7:30 - 7:45 PM  Opening Remarks
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B
7:45 - 9:45 PM  Keynote Session
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 

 

 

 

Monday, February 9
7:00 - 8:00 AM  Breakfast                                                             Tom Wilson Restaurant 
8:00 - 11:00 AM  Natural RNA Regulatory Pathways
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 
9:20 - 9:40 AM  Coffee Break                                                               Heritage Hall 
11:00 AM- 1:00 PM  Poster Setup                                                      Mount Temple C 
11:00 AM-  On Own for Lunch  
1:00 - 10:00 PM  Poster Viewing                                                         Mount Temple C 
4:30 - 5:00 PM  Coffee Available                                                               Heritage Hall 
5:00 - 7:15 PM  Medicinal Chemistry of Oligonucleotides
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 
7:15 - 8:15 PM  Social Hour w/ Lite Bites                                           Mount Temple C 
7:30 - 10:00 PM  Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple C 

 

 

Tuesday, February 10
7:00 - 8:00 AM  Breakfast                                                              Tom Wilson Restaurant 
8:00 - 11:00 AM  Mechanisms of Biodistribution of Oligonucleotides
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B
9:20 - 9:40 AM  Coffee Break                                                                   Heritage Hall 
11:00 AM- 12:00 PM  Lunch                                                        Tom Wilson Restaurant 
12:00 - 2:00 PM  Workshop: Issues with Target Validation Using Oligonucleotides
 Mount Temple A-B 
2:00 - 2:30 PM  Coffee Available                                                       Heritage Hall 
2:30 - 4:45 PM  Intersection of RNAi/miRNA Silencing with other Cellular Pathways (Innate Immunity, Editing, Intercellular Traffic of RNA, Viruses)
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 

 

 

Wednesday, February 11
7:00 - 8:00 AM  Breakfast                                                             Tom Wilson Restaurant 
8:00 - 11:00 AM  Target Validation
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B
9:20 - 9:40 AM  Coffee Break                                                                 Heritage Hall 
11:00 AM-  On Own for Lunch  
11:00 AM- 1:00 PM  Poster Setup                                                      Mount Temple C 
1:00 - 10:00 PM  Poster Viewing                                                         Mount Temple C 
4:30 - 5:00 PM  Coffee Available                                                              Heritage Hall 
5:00 - 7:00 PM  Nucleic Acids Formulations
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 

7:00 - 8:00 PM  Social Hour w/ Lite Bites                                            Mount Temple C 
7:30 - 10:00 PM  Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple C 

 

 

Thursday, February 12
7:00 - 8:00 AM  Breakfast                                                            Tom Wilson Restaurant 
8:00 - 11:00 AM  Non-Traditional RNA Targets as Therapeutic Opportunities
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 
9:20 - 9:40 AM  Coffee Break                                                              Heritage Hall 
11:00 AM-  On Own for Lunch  
4:30 - 5:00 PM  Coffee Available                                                         Heritage Hall 
5:00 - 7:00 PM  Clinical Trials
Registered attendees for this meeting can view Abstracts for this session starting on 01/08/2009  Mount Temple A-B 
7:00 - 8:00 PM  Social Hour w/ Lite Bites                                          Victoria Room 
8:00 - 11:00 PM  Entertainment                                                           Victoria Room 

 

 

 

Friday, February 13
 Departure 

 

*All deadlines end at 12:00 midnight US Mountain Standard Time

- You may register for this meeting on this web site until February 8, 2009.
- The Registration Fee includes the Abstract Submission Fee.
- For more information and other registration options, see How to Register.

Non-Student Fees
- The Registration Fee is $725.00 on and before December 8, 2008.
- After December 8, 2008, the Registration Fee is $825.00

Student Fees
- To qualify for the Student Discount, you must complete the Student Verification section of the Registration Form.
- The Student Registration Fee is $500.00 on and before December 8, 2008.
- After December 8, 2008, the Registration Fee is $600.00