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Mechanisms Of Aging: Key Effectors And Rational Targets

 

 

Chairs:
Janet Lord, Pamela L. Larsen & David A. Sinclair

 

Vice Chairs:
Ana Maria Cuervo, Rafa De Cabo & Pidder Jansen-Duerr

 

Application Deadline: Applications for this meeting must be submitted by January 25, 2009.

Please apply early, as some conferences become oversubscribed (full) before this deadline. If the conference is oversubscribed, it will be stated here. You will still be able to submit your application. However, it will only be considered by the Conference Chair if there are cancellations, making more seats available.

 

 

A central objective of this Biology of Aging Gordon Research Conference is to stimulate discussion of the interdependence of genetic, functional and environmental interactions in determining and potentially combating negative consequences of age-related changes and diseases. This includes investigations of structure and function that characterize normal aging and biochemical, genetic and physiological understanding of mechanisms of aging. Critically important for human wellbeing are investigations of the adverse changes that are risk factors, which contribute to or accompany age-related disease states in humans and animal models. Over the last several years a rudimentary understanding of some aging mechanisms have been generated. In organisms such as yeast, C. elegans and Drosophila, molecular genetic studies have defined many of the genes that determine life span and identification of which gene expression changes functionally associate with aging are underway. In rodents, many biochemical pathways strongly associate with aging and life span. These are now being confirmed and further studied using knockout and transgenic strategies. The insulin/insulin-like growth factor pathway appears to be an evolutionarily conserved mechanism that controls longevity and investigations into specific aspects of metabolism are revealing key effectors and potential targets. Thus, our field is continuing to mature as we develop a deeper understanding of aging mechanisms applicable across species and develop strategies to intervene in these processes in order to extend lifespan and health span.

The underlying goal of the program is to encourage participants to critically evaluate the latest insights into the aging process from the molecular to the whole organism, defining rational approaches to health span extension. There will be an emphasis upon aging at the integrative level and consideration of inflammation as a pleiotropic effector of the pathology associated with aging. Lifestyle, genetic, and pharmacological interventions will also form a significant element of the meeting program.
 

 

 

SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 7:45 pm Welcome / Introductory Comments by GRC Conference Chairs
7:45 pm - 9:30 pm  Keynote Address
7:45 pm - 7:55 pm Discussion Leader: Rafael de Cabo (NIA/NIH)
"Introduction"
7:55 pm - 8:40 pm Ian Deary (Edinburgh University, UK)
"Intelligence and Lifespan and Lifespan and Intelligence"
8:40 pm - 9:00 pm  Discussion

 

 

MONDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm  Structure and Function in the Aging Brain
9:00 am - 9:10 am Discussion Leader: George Martin (University of Washington)
"Introduction"
9:10 am - 9:45 am Heidi Scrable (University of Virginia)
"p53, adult neurogenesis and neurodegenerative disease"
9:45 am - 10:00 am  Discussion
10:00 am  Coffee Break
10:30 am - 11:00 am V Hugh Perry (Southampton University, UK)
"Impact of systemic inflammation on the aged brain and its consequences"
11:00 am - 11:10 am  Discussion
11:10 am - 11:40 am Eve van Cauter (University of Chicago)
"Impact of sleep and sleep disruption on neuroendocrine and metabolic function"
11:40 am - 11:50 am  Discussion
11:50 am - 12:20 pm Gro Amdam (Arizona State University & Norwegian University of Life Sciences)
"The plasticity of an aging brain: Understanding reversible learning impairment"
12:20 pm - 12:30 pm  Discussion
12:30 pm   Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm  Diseases of aging: genetics and epigenetics
7:30 pm - 7:35 pm Discussion Leader: Ed Lakatta (NIA/NIH)
"Introduction"
7:35 pm - 8:00 pm Lenny Guarente (MIT)
"SIRT1 deacetylates and positively regulates the nuclear receptor LXR"
8:00 pm - 8:15 pm  Discussion
8:15 pm - 8:40 pm Rolf Bodmer (Burnham Institute for Medical Research)
"Physiology and genetics of cardiac aging"
8:40 pm - 8:55 pm  Discussion
8:55 pm - 9:20 pm Jean Pierre Issa (University of Texas, MD Anderson Center)
"Progressive tissue specific changes in DNA methylation"
9:20 pm - 9:30 pm  Discussion

 

 

TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm  Factors influencing sarcopenia and muscle regeneration with age
9:00 am - 9:10 am Discussion Leader: Holly van Remmen (South Texas Veterans Health Care System, San Antonio & UTHSCSA)
"Introduction"
9:10 am - 9:45 am Tom Rando (Stanford University)
"Wnt signaling and age-related changes in stem cell fate"
9:45 am - 10:00 am  Discussion
10:00 am  Coffee Break
10:30 am - 11:00 am Kenneth Walsh (Boston University)
"Body composition changes upon aging: The role of type IIb muscle fibers"
11:00 am - 11:10 am  Discussion
11:10 am - 11:40 am Pere Puigserver (Harvard University)
"Nutrient-Dependent Metabolic Control Through the PGC-1 Pathway: Implications for Aging-Associated Diseases"
11:40 am - 11:50 am  Discussion
11:50 am - 12:20 pm Fred Goldberg (Harvard University)
"Molecular mechanisms of muscle wasting and the protective effects of exercise"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm  Aging and Cancer
7:30 pm - 7:35 pm Discussion Leader: Maria Blasco (Spanish National Cancer Research Center)
"Introduction"
7:35 pm - 8:00 pm Judy Campisi (Lawrence Berkeley National Laboratory)
"Cellular senescence links cancer and aging"
8:00 pm - 8:15 pm  Discussion
8:15 pm - 8:40 pm Manuel Serrano (Spanish National Cancer Research Center)
"Tumor suppressors in cancer and aging"
8:40 pm - 8:55 pm  Discussion
8:55 pm - 9:20 pm Anne Brunet (Stanford University)
"FOXO transcription factors in aging and stem cells"
9:20 pm - 9:30 pm  Discussion

 

 

WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm  Immunesenescence - basic mechanisms and targets for intervention
9:00 am - 9:10 am Discussion Leader: Arne Akbar (University College London)
"Introduction"
9:10 am - 9:45 am Janko Nikolich-Zugich (Oregon Health and Science University)
"Impact of acute and persistent infection upon function and homeostasis of an aging immune system - dysfunction and repair"
9:45 am - 10:00 am  Discussion
10:00 am  Coffee Break
10:30 am - 11:00 am Dennis Taub (NIA/NIH)
"Regulation of thymopoiesis by metabolic hormones"
11:00 am - 11:10 am  Discussion
11:10 am - 11:40 am Claudia Gravekamp (California Pacific Medical Center Research Institute)
"Are cancer vaccines effective at an older age?"
11:40 am - 11:50 am  Discussion
11:50 am - 12:20 pm John Tower (University of Southern California)
"Microbial load, autophagic immunity and drosophila lifespan"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm  Small molecule interventions to extend healthspan and lifespan
7:30 pm - 7:35 pm Discussion Leader: Monica Driscoll (Rutgers University)
"Introduction"
7:35 pm - 8:00 pm Linda Buck (Fred Hutchinson Cancer Research Center)
"A high throughput screen for chemicals that delay aging in Caenorhabditis elegans"
8:00 pm - 8:15 pm  Discussion
8:15 pm - 8:40 pm David Kipling (Cardiff University, UK)
"Small molecule intervention in stress signaling pathways in Werner Syndrome"
8:40 pm - 8:55 pm  Discussion
8:55 pm - 9:20 pm James Nelson (UTHSCSA)
"Pharmacologic and genetic interventions to probe mechanisms that extend longevity in mice" 9:20 pm - 9:30 pm  Discussion

 

 

THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm  Metabolism and longevity
9:00 am - 9:10 am Discussion Leader: Marc Tatar (Brown University)
"Introduction"
9:10 am - 9:45 am Michael Karin (University of California, San Diego)
"Stress activated kinases and degenerative diseases of obesity and old age"
9:45 am - 10:00 am  Discussion
10:00 am  Coffee Break
10:30 am - 11:00 am Leanne Jones (Salk Institute)
"Effects of InR signaling on maintenance and aging of the germ line"
11:00 am - 11:10 am  Discussion
11:10 am - 11:40 am Nir Barzilai (Albert Einstein College of Medicine)
"The decline in nutrient sensing mechanisms during mammalian aging"
11:40 am - 11:50 am  Discussion
11:50 am - 12:20 pm Christine Loh (Sirtris Pharmaceuticals)
"SIRT1 Activation - clinical utility"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
 (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm  Physiological human aging
7:30 pm - 7:35 pm Discussion Leaders: Vice Chairs Ana Maria Cuervo (Albert Einstein College of Medicine), Rafael de Cabo (NIA/NIH), and Pidder Jansen-Duerr (Institute for Biomedical Aging Research, Innsbruck)
"Introduction"
7:35 pm - 8:00 pm Luigi Ferrucci (NIA/NIH)
"Baltimore Longitudinal Study: the effects of aging independent of disease"
8:00 pm - 8:10 pm  Discussion
8:10 pm - 8:35 pm Chitty Chen (University of Ghent, Belgium)
"Proteomics and metabolomics of human aging"
8:35 pm - 8:55 pm  Discussion
8:55 pm - 9:20 pm Eric Ravussin (Pennington Biomedical Research Center)
"Caloric restriction trials in humans"
9:20 pm - 9:30 pm  Discussion

 

 

FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure