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The current studies on Dendritic Cells (DCs) have confirmed not only their major role as antigen presenting cells in adaptive immunity but also their important functions in the initiation of the innate resistance and inflammatory responses. DCs are thus an important bridge between innate resistance and adaptive immunity either through cellular interactions or secretion of pro-inflammatory and immunoregulatory cytokines. The origin and migration pattern of DCs as well as their sharing of hematopoietic lineages, functions, and receptors with other phagocytic cell types such as monocytes and macrophages is a subject of intense investigation. The special characteristics of antigen processing and expression of immunoregulatory gene products in DCs are central in their ability to either activate and tolerize T cells and on their in vivo functions in degenerative, autoimmune and infectious diseases as well as in cancer. In this symposium, the following aspects of DC biology will be emphasized: (1) DC precursors and relation with monocyte and macrophages; (2) receptors, phagocytosis, and antigen presentation; (3) regulation of type I IFN production; (4) DCs in tolerance, immunity, and T cell activation; and (5) DCs in cancer and other diseases.

 

 

 

Sunday, March 29
3:00 - 7:30 PM  Registration                                                                  Van Horne Foyer 
6:30 - 7:30 PM  Refreshments                                                               Van Horne Foyer 
7:30 - 9:30 PM  Keynote Session (Joint)                                                Van Horne Ballroom 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009
 Shizuo Akira, Osaka University, Japan
TLRs and Inflammation  
 Ira Mellman, Genentech, Inc., USA
Cell Biology of Antigen Processing by Dendritic Cells  

 

Monday, March 30
7:00 - 8:00 AM  Breakfast                                                                  Mezzanine 2 
7:00 - 8:00 AM  Poster Setup                                                            Mezzanine 2 
8:00 - 11:00 AM  Phagocytosis and Antigen Presentation 

Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom A,B 
Sebastian Amigorena, Institut Curie, France
Pathways for Antigen Cross Presentation   
David G. Russell, Cornell University, USA
Reprogramming Phagosomal Function in Macrophages and Dendritic Cells  
Jose A. Villadangos, Walter and Eliza Hall Institute of Medical Research, Australia
Antigen Presentation Specializations in the Dendritic Cell Network   
Bali Pulendran, Emory University, USA
Modulating vaccine responses with innate immunity  
Short Talk(s) to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
8:00 - 11:00 AM  TLRs - I                                               Van Horne Ballroom C 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009    
Richard A. Flavell, Yale University School of Medicine, USA
Pattern Recognition Molecules and Signal Transduction Pathways  
Bruce A. Beutler, The Scripps Research Institute, USA
Mutagenesis in the analysis of pathogen sensing pathways  
Luke A.J. O'Neill, Trinity College Dublin, Ireland
The IL-1 receptor / Toll-like receptor superfamily: 10 years of progress  
Ruslan M. Medzhitov, Yale University School of Medicine, USA

9:20 - 9:40 AM  Coffee Break                                                            Van Horne Foyer 
11:00 AM- 12:00 PM  Lunch                                                                 Mezzanine 2 
12:00 - 2:30 PM  Poster Session 1                                                       Mezzanine 2 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009 
12:00 - 5:00 PM  Poster Viewing                                                            Mezzanine 2 
2:30 - 4:30 PM  Workshop 1: PAMPS as a Link between Adaptive and Innate Immunity (Joint)
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom 
Short Talks to be Chosen from Abstracts, , USA 
4:30 - 5:00 PM  Coffee Available                                                          Van Horne Foyer 
5:00 - 7:00 PM  DCs in Tolerance, Immunity, and T Cell Differentiation
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom A,B 
Daniel J. Cua, Schering-Plough Biopharma, USA
The IL-23/IL-17 Axis  
Yong-Jun Liu, University of Texas MD Anderson Cancer Center, USA
Thymic Stromal Lymphopoietin Program Dendritic Cells to Induce TH2 Inflammation through a Unique Set of Signal Codes  
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Tim-3 and Expansion of Regulatory Antigen Presenting Cells  
Short Talk to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
5:00 - 7:00 PM  TLRs - II                                                Van Horne Ballroom C 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  

7:00 PM-  On Own for Dinner  

 

Tuesday, March 31
7:00 - 8:00 AM  Breakfast                                                                Mezzanine 2 
8:00 - 11:00 AM  Dendritic Cell Precursors                          Van Horne Ballroom A,B 
 Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009     
Carlos Ardavin, National Center for Biotechnology, Spain
Monocyte-Derived Dendritic Cells  
Steffen Jung, Weizmann Institute of Science, Israel
Probing Origins and In Vivo Functions of Dendritic cells  
Markus G. Manz, Institute for Research in Biomedicine, Switzerland
Lymphoid-Organ Dendritic Cell Homeostasis in Steady-State and Inflammation  
Boris Reizis, Columbia University, USA
Plasmacytoid Dendritic Cell Differentiation  
Short Talk(s) to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
8:00 - 11:00 AM  NLR/NBD-LRR Proteins, Pathways and Diseases
 Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom C 
Jonathan D.G. Jones, Sainsbury Laboratory, UK
Using Pathogen Effectors to Understand Host Resistance Mechanisms  
Jenny P. Ting, University of North Carolina at Chapel Hill, USA
NLR in Disease and in Health  
Vishva M. Dixit, Genentech, Inc., USA
The Inflammasone: A Dynamic Caspase Activating Apparatus  
John C. Reed, Burnham Institute for Medical Research, USA
Linking Innate Immunity with the Cell Death Machinery: Interactions of NLR and Bcl-2 Family Proteins  

9:20 - 9:40 AM  Coffee Break                                                                   Van Horne Foyer 
11:00 AM- 1:00 PM  Poster Setup                                                            Mezzanine 2 
11:00 AM-  On Own for Lunch  
1:00 - 10:00 PM  Poster Viewing                                                               Mezzanine 2 
4:30 - 5:00 PM  Coffee Available                                                               Van Horne Foyer 
5:00 - 7:00 PM  Recent Advances                                    Van Horne Ballroom A,B

Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  
Dominique Kaiserlian, INSERM, France
Role of Liver Plasmacytoid DC in Oral Tolerance  
Yvette van Kooyk, Vrije University Medical Center, Netherlands
Targeting of DC by Glycosylated Antigens   
Ana-Maria Lennon-Dumenil, Institut Curie, France
Coordinated Antigen Presentation and Dendritic Cell Migration  
Short Talk to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
5:00 - 7:00 PM  NLR/NBD-LRR Proteins, Pathways and Diseases - II
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom C 
Jürg Tschopp, University of Lausanne, Switzerland
Malarial hemozoin is a Nalp3 inflammasome activating danger signal  
Gabriel Nuñez, University of Michigan, USA
Function of Nod-like Receptors in Innate Immunity  
Dana Philpott, University of Toronto, Canada
Nod Proteins and the Interaction of Innate and Adaptive Immunity  

7:00 - 8:00 PM  Social Hour w/ Lite Bites                                             Mezzanine 2 
7:30 - 10:00 PM  Poster Session 2                                                      Mezzanine 2 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009 

Wednesday, April 1
7:00 - 8:00 AM  Breakfast                                                                      Mezzanine 2 
8:00 - 11:00 AM  Dendritic Cells in Disease                                 Van Horne Ballroom A,B 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  
Miriam Merad, Mount Sinai Medical Center, USA
Origin of Dendritic Cell Diversity Controls Tissue Immunity  
Gwendalyn J. Randolph, Mount Sinai School of Medicine, USA
Monocytes, dendritic cells, and their migration in atherosclerosis  
Maria Rescigno, European Institute of Oncology, Italy
DCs in Intestinal Disease  
Giorgio Trinchieri, National Cancer Institute at Frederick, USA
TLR Signaling in DC: Lessons from Fibroblasts  
Short Talk(s) to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
8:00 - 11:00 AM  Viral Sensors                                                     Van Horne Ballroom C 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  
Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors  
Hong-Bing Shu, Wuhan University, China
Virus-triggered signaling pathways  
Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK
Innate Anti-Viral and Fungal Responses  
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
A Novel DNA Sensor for Virus Infection  

9:20 - 9:40 AM  Coffee Break                                                      Van Horne Foyer 
11:00 AM- 1:00 PM  Poster Setup                                              Mezzanine 2 
11:00 AM-  On Own for Lunch  
1:00 - 10:00 PM  Poster Viewing                                                 Mezzanine 2 
2:30 - 4:30 PM  Workshop 2: Systems Biology of Dendritic Cells; Supported by the Society for Mathematical Biology

NOTE: The immune system acts across multiple scales of space and time involving complex interactions and feedback. Computational modeling provides a framework to integrate observational data collected from multiple modes of experimentation and can provide insight into immune cell function in health and disease. Computational approaches have been increasingly applied to problems in immunology, providing methods that range from the inference of transcriptional programs to the prediction of drug treatment effects on viral dynamics. This workshop will cover recent advances and potential applications of computational modeling and methods to dendritic cells.
Van Horne Ballroom A,B 
Speakers to be Announced, 
4:30 - 5:00 PM  Coffee Available                                                      Van Horne Foyer 
5:00 - 7:00 PM  Regulation of Type I Interferon Production
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom C  

Akiko Iwasaki, Yale University School of Medicine, USA
Autophagy-dependent antigen presentation by dendritic cells  
Keiko Ozato, NICHD, National Institutes of Health, USA
Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells  
Gunther Hartmann, Universitätsklinikum Bonn, Germany
Ligands for RIG-I: Induction of IFN by siRNA  
Short Talk to be Chosen from Abstracts, 
Following Session is for Immune Pattern Recognition (Z1)
5:00 - 7:00 PM  Evolution of Pattern Recognition Molecules
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom C 
Max D. Cooper, Emory University, USA
Evolution of LRR- Based Variable Lymphocyte Receptors   
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Drosophila Pathogen Sensors  
Frederick M. Ausubel, Massachusetts General Hospital, USA
Innate Immunity in C. elegans  

7:00 - 8:00 PM  Social Hour w/ Lite Bites                                              Mezzanine 2 
7:30 - 10:00 PM  Poster Session 3                                                       Mezzanine 2 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009 

 

Thursday, April 2
7:00 - 8:00 AM  Breakfast                                                                      Mezzanine 2 
7:00 - 8:00 AM  Poster Setup                                                                 Mezzanine 2 
8:00 - 11:00 AM  PRRs in Dendritic Cells and Macrophages (Joint)
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom 
Marco Colonna, Washington University School of Medicine, USA
MDA5, TLRs and Dendritic Cells  
Gordon D. Brown, University of Cape Town, South Africa
Dectin-1 and Antifungal Responses  
Alan Sher, NIAID, National Institutes of Health, USA
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites  
Christine A. Biron, Brown University, USA
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets  
Short Talk(s) to be Chosen from Abstracts, 
9:20 - 9:40 AM  Coffee Break                                                               Van Horne Foyer 
11:00 AM- 12:00 PM  Lunch                                                                Mezzanine 2 
12:00 - 2:30 PM  Poster Session 4                                                      Mezzanine 2 
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009 
12:00 - 5:00 PM  Poster Viewing                                                         Mezzanine 2 
4:30 - 5:00 PM  Coffee Available                                                    Van Horne Foyer 
5:00 - 6:40 PM  Dendritic Cells in Cancer and Cancer Therapy
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom A,B 
Jacques F. Banchereau, Baylor Institute for Immunology Research, USA
Cancer Associated Dendritic Cells  
Guido Kroemer, INSERM, U848, Institut Gustave Roussy, France
Immunogenic Cell Death for Optimal Anti-Cancer Chemotherapy   
Carl G. Figdor, Radboud University Nijmegen Medical Centre / NCMLS, Netherlands
Human plasmacytoid dendritic cells in cancer and cancer therapy  
Following Session is for Immune Pattern Recognition (Z1)
5:00 - 7:00 PM  SNPs, Clinical Diseases and Pattern Recognition Molecules/Sensors
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom C 
Adrian V.S. Hill, Jenner Institute, Oxford University, UK
Innate Immunity Polymorphisms and Susceptibility to Human Infectious Diseases  
Judy H. Cho, Yale School of Medicine, USA
NOD2, Innate Immunity and Human Diseases  
Daniel Kastner, National Institutes of Health, USA
NLR and Autoinflammatory Diseases: From Mechanisms to Treatment  

6:40 - 7:15 PM  Concluding Remarks
Registered attendees for this meeting can view Abstracts for this session starting on 02/28/2009  Van Horne Ballroom A,B 
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells: Translating Innate to Adaptive Immunity to Help Discover Vaccines  
7:15 - 8:15 PM  Social Hour w/ Lite Bites                                         Mezzanine 2 
8:15 - 11:00 PM  Entertainment                                                         Mezzanine 2 

 

 

Friday, April 3
 Departure 

 

 

- You may register for this meeting on this web site until March 29, 2009.
- The Registration Fee includes the Abstract Submission Fee.
- For more information and other registration options, see How to Register.

 

Non-Student Fees
- The Registration Fee is $725.00 on and before January 29, 2009.
- After January 29, 2009, the Registration Fee is $825.00

 

Student Fees
- To qualify for the Student Discount, you must complete the Student Verification section of the Registration Form.
- The Student Registration Fee is $500.00 on and before January 29, 2009.
- After January 29, 2009, the Registration Fee is $600.00