행사/교육
Kinase Signaling in Disease
- 등록일2009-01-13
- 조회수2218
- 구분 국외
- 행사교육분류 행사
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주관기관
http://www.keystonesymposia.org/
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행사장소
Keystone Symposia - Olympic Valley, CA
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행사기간
2009-04-22 ~ 2009-04-27
- 원문링크
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첨부파일
Kinase Signaling in Disease
Meeting Summary
The PI 3-kinase signaling pathway controls multiple physiological processes including cell growth, cell proliferation and cell movement. Dysregulation of this pathway in cancer, inflammation and heart disease has led to the emergence of PI 3-kinase as a promising
therapeutic target. One of the most exciting developments in this field is the discovery of new PI 3-kinase inhibitors. The balance between modulating PI 3-kinase activity in pathophysiological setting, whilst avoiding unwanted side-effects, is the subject of intense debate. In addition, as PI 3-kinase is a member of a multigene family, the rationale for inhibiting individual isoforms or multiple isoforms of PI 3-kinase is constantly changing. This
meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI 3-kinase pathway in disease, drawing on human pathophysiology and genetics, mouse models and preclinical data with
new PI 3-kinase inhibitors.
Meeting Program
Wednesday, April 22
3:00 - 7:30 PM Registration Lobby Alcove
6:30 - 7:30 PM Refreshments Sierra Prefunction A,B,C,D
7:30 - 8:30 PM Keynote Address Grand Sierra Ballroom
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
William R. Sellers, Novartis Institutes for BioMedical Research, USA
Development of PI3K Pathway Modulators for Cancer
Thursday, April 23
7:00 - 8:00 AM Breakfast Alpine Ballroom
8:00 - 11:00 AM Phosphoinositides and Signaling (Joint) Grand Sierra Ballroom
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Lewis C. Cantley, Harvard Medical School, USA
Growth Control by the PI3K/mTOR Pathway
Len R. Stephens, Babraham Institute, UK
The Role of PI3K's in the Regulation of the Neutrophil NADPH Oxidase
Speaker to be Announced,
Mark A. Lemmon, University of Pennsylvania School of Medicine, USA
PH Domains and Other Phosphoinositide & Phospholipid Binding Domains
9:20 - 9:40 AM Coffee Break Sierra Prefunction A,B,C,D
11:00 AM- 1:00 PM Poster Setup Cascades / Restaurant
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Cascades / Restaurant
4:30 - 5:00 PM Coffee Available Sierra Prefunction A,B,C,D
5:00 - 7:00 PM PI3 Kinase Pathway and Inflammation Grand Sierra A,B
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Phillip T. Hawkins, Babraham Institute, UK
PI3K Signaling in Neutrophils
Matthias P. Wymann, University of Basel, Switzerland
PI3-Kinase Signaling in Immune Cells
Speaker to be Announced,
Following Session is for Complex Lipids in Biology (Z4)
5:00 - 7:00 PM Phospholipases and Acyl Transferases Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Christina C. Leslie, National Jewish Medical and Research Center, USA
cPLA2 Isoforms: Biochemistry and Function
Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation
Michael J.O. Wakelam, Babraham Institute, UK
Phospholipase D and Disease
7:00 - 8:00 PM Social Hour w/ Lite Bites Cascades / Restaurant
7:30 - 10:00 PM Poster Session 1 Cascades / Restaurant
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Friday, April 24
7:00 - 8:00 AM Breakfast Alpine Ballroom
8:00 - 11:00 AM PI 3-Kinase Signaling: Downstream Effectors Grand Sierra A,B
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Bart Vanhaesebroeck, Barts & The London School of Medicine, UK
Roles of PI3 Kinase Isoforms
Kevan M. Shokat, University of California, San Francisco, USA
Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2.
Ana Clara Carrera, Centro Nacional Biotechnologia, Spain
Distinct activation requirements and function for Phosphoinositide 3-kinase p110alpha and beta in cell division
Levi A. Garraway, Dana Farber Cancer Institute, USA
Talk Title to be Determined
Following Session is for Complex Lipids in Biology (Z4)
8:00 - 11:00 AM Leukotrienes: New Frontiers Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Jilly F. Evans, Amira Pharmaceuticals, USA
5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target
Marc Peters-Golden, University of Michigan, USA
Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation
Robert C. Murphy, University of Colorado Denver, USA
Transcellular Biosynthesis of Leukotrienes
Colin D. Funk, Queen's University, Canada
Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns
9:20 - 9:40 AM Coffee Break Sierra Prefunction A,B,C,D
11:00 AM- 1:00 PM Poster Setup Cascades / Restaurant
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Cascades / Restaurant
4:30 - 5:00 PM Coffee Available Sierra Prefunction A,B,C,D
5:00 - 7:00 PM Cell Growth, Metabolism and Aging Grand Sierra A,B
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Crosstalk between PI3K and mTOR
Speaker to be Announced,
Anne Brunet, Stanford University, USA
Role of FOXO Transcription Factors in Aging
Following Session is for Complex Lipids in Biology (Z4)
5:00 - 7:00 PM Sphingolipid Signaling Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Timothy T. Hla, University of Connecticut, USA
S1P Signaling in the Vasculature
Shaun R. Coughlin, University of California, San Francisco, USA
Compartmentalization of S1P Signaling
Richard L. Proia, National Institutes of Health, USA
Sphingosine-1-Phosphate and its Role in Physiology
7:00 - 8:00 PM Social Hour w/ Lite Bites Cascades / Restaurant
7:30 - 10:00 PM Poster Session 2 Cascades / Restaurant
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Saturday, April 25
7:00 - 8:00 AM Breakfast Alpine Ballroom
8:00 - 11:00 AM PI 3-Kinase Signaling and Cancer Grand Sierra A,B
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Pier Paolo Pandolfi, Harvard Medical School/BIDMC, USA
PTEN and the Control of Tumorigenesis
Tak W. Mak, Campbell Family Institute for Breast Cancer Research at PMH, UHN, Canada
PI 3-Kinase Signaling and Tumorigenesis
Jean Zhao, Dana-Farber Cancer Institute, USA
Class IA PI3K Isoforms in Signaling and Cancer
Jeffrey Adam Engelman, Massachusetts General Hospital, USA
Talk Title to be Determined
Following Session is for Complex Lipids in Biology (Z4)
8:00 - 11:00 AM Ceramides, LysoPA and Other Lipid Mediators Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Jerold J. Chun, The Scripps Research Institute, USA
Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms
Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA
Signaling and Compartmentalization of Sphingosine-1-Phosphate
Teresa M. Dunn, Uniformed Services University of the Health Sciences, USA
Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Multidimensional Profiling and Lipid Ether Signaling
9:20 - 9:40 AM Coffee Break Sierra Prefunction A,B,C,D
11:00 AM- 1:00 PM Poster Setup Cascades / Restaurant
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Cascades / Restaurant
2:30 - 4:30 PM Workshop: Targeting PI3 Kinase: Insights from Drug Discovery Projects
Short Talks to be Chosen from Abstracts, , USA
4:30 - 5:00 PM Coffee Available Sierra Prefunction A,B,C,D
5:00 - 7:00 PM Phosphatases and Control of the PI 3-Kinase Pathway / Grand Sierra A,B
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Alexandra C. Newton, University of California, San Diego, USA
Signal Termination: PHLiPPing the Switch in Cell Signaling
Nick Reid Leslie, University of Dundee, UK
The Regulation and Mechanisms of Action of PTEN
Takehiko Sasaki, Akita University School of Medicine, Japan
In vivo Roles of Phosphoinositide Phosphatases
Following Session is for Complex Lipids in Biology (Z4)
5:00 - 7:00 PM Recent Advances in PGH Synthate and 5-lipoxygenase/Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
William L. Smith, University of Michigan, USA
Cyclooxygenase Homodimers Function as Conformational Heterodimers with Allosteric and Catalytic Subunits
Garret A. FitzGerald, University of Pennsylvania, USA
Translational Therapeutics of the Arachidonic Acid Cascade
Frank A. Fitzpatrick, University of Utah, USA
Akt Activation by Arachidonic Acid Metabolism
7:00 - 8:00 PM Social Hour w/ Lite Bites Cascades / Restaurant
7:30 - 10:00 PM Poster Session 3 Cascades / Restaurant
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Sunday, April 26
7:00 - 8:00 AM Breakfast Alpine Ballroom
8:00 - 11:00 AM PI 3-Kinase Pathway Modulation: Transition to the Clinic I
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009 Grand Sierra A,B
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Integration of PI3K and ERK Signaling--Therapeutic Implications
Richard F. Wooster, GlaxoSmithKline, USA
Talk Title to be Determined
Christian Rommel, Intellikine, USA
Talk Title to be Determined
Speaker to be Announced,
Following Session is for Complex Lipids in Biology (Z4)
8:00 - 11:00 AM Phospholipases, Kinases and Signaling Systems Grand Sierra C,D
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009
Michael A. Frohman, Stony Brook University, USA
Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways
H. Alex Brown, Vanderbilt University, USA
Signaling Lipid Analysis and Phospholiase D
Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine-1-phosphate, a determinant of mast cell responsiveness
Julie D. Saba, Children’s Hospital Oakland Research Institute, USA
S1P Lyase in Development and Disease: Sphingolipid Metabolism Takes Flight
9:20 - 9:40 AM Coffee Break Sierra Prefunction A,B,C,D
11:00 AM- On Own for Lunch
4:30 - 5:00 PM Coffee Available Sierra Prefunction A,B,C,D
5:00 - 7:00 PM PI 3-Kinase Pathway Modulation: Transition to the Clinic II
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009 Grand Sierra A,B
Paul Workman, Institute of Cancer Research, UK
Drugging the PI3 Kinome for Cancer Treatment
Speakers to be Announced,
Following Session is for Complex Lipids in Biology (Z4)
5:00 - 7:00 PM Polyunsaturated Fatty Acids and Lipid Peroxidation
Registered attendees for this meeting can view Abstracts for this session starting on 03/22/2009 Grand Sierra C,D
Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Novel Strategies to Identify Lipid-Protein Covalent Adducts
Suzanne E. Barbour, Virginia Commonwealth University, USA
Lipoprotein-Associated PLAA2/ PAF-AH: An Important Enzyme in Metabolic Diseases
Speaker to be Announced,
7:00 - 8:00 PM Social Hour w/ Lite Bites Cascades / Restaurant
8:00 - 11:00 PM Entertainment Cascades / Restaurant
Monday, April 27
Departure
Registration Deadlines and Pricing
NOTE: Please use buttons in blue bar above to Register Yourself, or to Register a Colleague
*All deadlines end at 12:00 midnight US Mountain Standard Time
- You may register for this meeting on this web site until April 22, 2009.
- The Registration Fee includes the Abstract Submission Fee.
- For more information and other registration options, see How to Register.
Non-Student Fees
- The Registration Fee is $645.00 on and before February 23, 2009.
- After February 23, 2009, the Registration Fee is $745.00
Student Fees
- To qualify for the Student Discount, you must complete the Student Verification section of the Registration Form.
- The Student Registration Fee is $420.00 on and before February 23, 2009.
- After February 23, 2009, the Registration Fee is $520.00
What is included in the registration fee?
- Admission to plenary speaker talks and poster displays
- Abstract book
- Breakfast service and coffee breaks
- Refreshments at poster sessions
Registration fee generally does NOT include:
- Lodging
- Transportation
- Lunches (some locations will provide lunch instead of evening social hour food...check program for specifics)
- Dinners