바이오인

 
12:15
Microwave Mediated Peptide Synthesis in Comparison to Conventional Peptide Synthesis Wolfgang Rapp, CEO, Rapp Polymere
All investigated examples show clearly that synthesis performed under microwave irradiation give no benefit over synthesis performed with conventional heating. In all cases, microwave irradiation has only a thermal effect.
 
12:45
Lunch & Networking in Main Exhibition Hall
 
2:30
Hazardous Nitration using Microreactor-From Laboratory to Production
Mehul Tathagar, Research Scientist, DSM
 
3:00
Title to be Confirmed
David Parry, Managing Director, Cyclofluidic
 
3:30
Technology Spotlight
 
3:45 
Coffee & Networking in Main Exhibition Hall    
 
4:15
Improving Organic Synthesis by Exploiting Flow Reactor Technology
Paul Watts, Senior Lecturer, University of Hull
In this presentation a number of chemical reactions of industrial interest will be used to illustrate the advantages that flow reactors offer for the rapid optimisation of reactions, in which the product is typically produced in both higher yield and purity. It will be illustrated that compounds may be prepared and purified within an integrated system and that it is possible to generate intermediates in situ within the reactor, which may then be subsequently reacted to produce more complex products. More recently the incorporation of solid supported reagents and catalysts has been investigated and the results will be discussed. The use of solid supported reagents adds even greater diversity to the range of reactions that may be achieved within such systems. It will be demonstrated that the dimensions of reactors may be increased in size while maintaining the classic advantages associated with miniaturisation. In such systems significant quantities of analytically pure compound may be prepared without additional purification.
 
4:45
Complex Target Synthesis Using Reactive Metal Carbenoids
Stephen Clark, Professor, Glasgow University
The lecture will focus on the rapid construction of complex polycyclic structures using the reactions of copper and rhodium carbenoids and the rearrangement of highly reaction intermediates generated from them. The application of this methodology to the total synthesis of bioactive natural products will be discussed.
 
5:15
Drinks Reception
For Sponsorship please contact Exhibition Manager a.woodley@selectbiosciences.com
 
 
Day 2 - Friday 17th April 2009
 
08:55
Session: Advances in Synthesis Techniques and Technologies
Chair: Mark Bagley, Senior Lecturer, Cardiff University
 
09:00
Key Note Presentation
Synthesis of Cell Delivery Agents
Mark Bradley, Professor, University of Edinburgh
 
09:30
Approaches to the Total Synthesis of Some Biologically Active Natural Products
Jim Thomas, Professor, Manchester University
Stereoselective procedures for the synthesis of compounds with methyl groups at 1,5,9, 13- and 1,3,5,7--positions down unfunctionalised aliphatic chains will be described together with approaches to some complex biologically active natural products including phomactin A and bryostatins.
 
10:00
The Big Leap - Turning Bench Chemistry to Full Scale Processes
Hans-Jürgen Federsel, Director of R&D, AstraZeneca
With the design of more and more structurally challenging molecules as candidate drugs, there is an ever increasing demand on Process R&D for being able to cope with their large scale preparation using safe and environmentally considerate methods at acceptable costs.
 
10:30
Coffee & Networking in Exhibition Hall
 
11:15
Synthesis Based on Alkenyl-hem-dichlorocyclopropanes
Semen Zlotsky, Professor, Ufa State Tech University
 
11:45
Session: Flow Chemistry
Chair: Ferenc Darvas, President, Thales Nano
 
11:50
Key Note Presentation
Horizons in Flow Chemistry
Ferenc Darvas, President, Thales Nano
Recent progress in flow chemistry summarized: flash chemistry under regular and supercritical conditions,
residence-time controlled flow chemistry, methatesis under flow conditions, a highly efficient method for deuteration
in flow. Establishing kinetic and diffusion controlled areas in the reaction space by flow methods.
 
12:20
Scaling up of Continuous Reactors
Robert Ashe, Director, AM Technology
 
12:50
Lunch & Networking in Main Exhibition Hall
 
2:30
Key Note Presentation
Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions
Oliver Kappe, Professor, Karl-Franzens-University Graz
Reaction conditions typical for microwave batch reactors can be mimicked in a high temperature high-pressure flow reactor. In the microtube flow device, many of the benefits inherent to microwave chemistry such as rapid heating/cooling and sealed vessel processing can be mimicked, including the generation of solvents in their supercritical state.
 
3:00
New Organopalladium Chemistry for Heteroarene Arylation
Michael Greaney, Professor, University of Edinburgh
 
3:30
Technology Spotlight
 
3:45
Coffee & Networking in Main Exhibition Hall
 
4:15
Technology Networks Poster Award Ceremony
 
4:25
Continuous Flow Microreactors for Heterogeneously Catalyzed and High Pressure Reactions
Willen Verboom, Associate Professor, University of Twente
Catalyst-functionalized brushes as a coating of the inner wall of glass micro-reactors give rise to considerable rate enhancements compared to lab scale. Another interesting application of microreactors is their use at high pressures, without the need for strict safety regulations.
 
4:55
TBC
 
5:25
Close of Conference
 

 

Microwave-Assisted Organic Synthesis

Obtain a state of the art introduction and training in this dynamic field
Understand the theory and concepts behind microwave synthesis
Become familiar with all major types of commercially available microwave reactors from different vendors
Learn to apply microwave chemistry to your synthetic chemistry problems
Hear about a diverse set of chemistries and applications during the course
Find out about future trends in microwave chemistry in particular in process and scale-up
Discover where to look for more advanced information, using the extensive references provided

This course aims to provide practical information for the synthetic chemist charged with the task of purification of synthesis reaction mixtures.

The course starts by introducing the basics of Solid Phase Extraction.
Following on from this the course then specifically deals with principles and techniques that can be applied to synthesis chemistry reaction mixture clean up.