바이오인

APOPTOTIC CELL RECOGNITION & CLEARANCE

 

June 28 - July 3, 2009
Colby-Sawyer College
New London, NH

 

Chairs:
Martin Herrmann & Yoshinobu Nakanishi

 

Vice Chairs:
Adam Lacy-Hulbert & Chris Gregory

 

 

Application Deadline: Applications for this meeting must be submitted by June 7, 2009.

Please apply early, as some conferences become oversubscribed (full) before this deadline. If the conference is oversubscribed, it will be stated here. You will still be able to submit your application. However, it will only be considered by the Conference Chair if there are cancellations, making more seats available.

 

Apoptosis plays a key role in the morphogenesis during development and in the maintenance of tissue homeostasis in adults. Its mechanisms have been intensely studied, and early stages of apoptosis are about to be fully understood. The fate of later stage apoptotic cells remain to be characterized.

The 2009 GRC on Apoptotic Cell Recognition & Clearance will present up-to-date research on the molecular, cellular and immunological aspects of the clearance of dying cells. It will feature a wide range of topics, like tissue homeostasis, stress-response, inflammation, and immunology and will focus on the importance of the clearance of apoptotic cells when investigating development, morphogenesis, tolerance, autoimmunity, and immune privilege. The invited speakers represent a variety of scientific disciplines, including developmental research, genetics, signaling, immunology, medicine, and cell biology. Data on various multicellular organisms from worm to human will be presented. The conference will provide a platform for investigators who are at the forefront of their field, and will welcome junior scientists and graduate students presenting their work in poster format to exchange ideas and hypotheses with leaders in the field. We encourage all poster presenters to give short on-spot talks during extended poster sessions. Some of the posters will also be selected for talks in the main auditory.

The conference provides a forum for:

 

- sharing the latest knowledge on fundamental issues how phagocytic cells recognize apoptotic cells and how pathways for the induction of phagocytosis are activated;
- clarifying implications of apoptotic cell clearance in morphogenesis and homeostasis;
- understanding recent progress in clinical applications;
- evaluating topics outside the main issues of this conference;
- exchanging questions/answers, opinions, ideas and data from ongoing experiments to create collaborations.

The collegial atmosphere of this conference, with opportunities for informal gatherings, promotes cross-disciplinary collaborations in the various research areas represented.
 

SUNDAY
2:00 pm - 11:00 pm Arrival and Check-in
6:00 pm Dinner
7:30 pm - 7:35 pm Welcome / Introductory Comments by GRC Site Staff
7:35 pm - 7:40 pm Introductory Comments by Chairs: Martin Herrmann and Yoshinobu Nakanishi
7:40 pm - 9:30 pm The Beginnings: The Mechanisms and Consequences of Apoptotic Cell Clearance (Keynote Presentations)
 Discussion Leader: Robert Schlegel (Pennsylvania State University)
7:40 pm - 8:15 pm  John Savill (University of Edinburgh)
"The meaning of apoptotic cell phagocytosis"
8:15 pm - 8:35 pm  Discussion
8:35 pm - 9:10 pm  Donna Bratton (National Jewish Medical and Research Center)
"The mechanism of apoptotic cell phagocytosis"
9:10 pm - 9:30 pm  Discussion

 

MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Recognition: The Way Phagocytes Find Their Targets
 Discussion Leader: David Ucker (University of Illinois)
9:00 am - 9:25 am  Pat Williamson (Amherst College)
"The guts of the machine: Insights into the mechanism of lipid transport"
9:25 am - 9:35 am  Discussion
9:35 am - 10:00 am  Ding Xue (University of Colorado)
"PS externalization and cell corpse recognition in C. elegans"
10:00 am - 10:10 am  Discussion
10:10 am - 10:45 am  Coffee Break / Group Photo
10:45 am - 11:10 am  Shige Nagata (Kyoto University, Japan)
"Tim4 as a phosphatidylserine receptor"
11:10 am - 11:20 am  Discussion
11:20 am - 11:45 am  In-San Kim (Kyungpook National University, Korea)
"Stabilin-2 as a phosphatidylserine receptor"
11:45 am - 11:55 am  Discussion
11:55 am - 12:20 pm  Kodi Ravichandran (University of Virginia)
"BAI1 as a phosphatidylserine receptor"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session 1
6:00 pm Dinner
7:30 pm - 9:30 pm The Response: Maintenance of Tissue Homeostasis through Removal of Dying Cells
 Discussion Leader: Angelo Manfredi (DIBIT Milano, Italy)
7:30 pm - 7:50 pm  Stephen P. Schoenberger (La Jolla Institute for Allergy and Immunology)
"Cross-presentation of apoptotic cell antigens"
7:50 pm - 8:00 pm  Discussion
8:00 pm - 8:20 pm  Patrizia Rovere-Querini (DIBIT Milano, Italy)
"Innate response to cell death: tissue remodeling and stem cell recruitment"
8:20 pm - 8:30 pm  Discussion
8:30 pm - 8:40 pm  Kerstin Sarter (University of Erlangen-Nürnberg, Germany)
"Galectins as ligands for late apoptotic cells"
8:40 pm - 8:50 pm  Discussion
8:50 pm - 9:00 pm  Udo S. Gaipl (University of Erlangen-Nürnberg, Germany)
"Annexins as immune modulators"
9:00 pm - 9:10 pm  Discussion
9:10 pm - 9:25 pm  Masato Tanaka (RIKEN, Japan)
"Mechanism of tolerance induction to cell-associated antigens by apoptotic cell clearance"
9:25 pm - 9:30 pm  Discussion

 

TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Players: Newly Identified Molecules Working at the Onset of Clearance
 Discussion Leader: Yoshiro Kobayashi (Toho University, Japan)
9:00 am - 9:25 am  Nathalie Franc (University College London)
"Undertaker/Retinophilin, a Drosophila Junctophilin links Draper and drCed-6 to calcium homeostasis during phagocytosis"
9:25 am - 9:35 am  Discussion
9:35 am - 10:00 am  Zheng Zhou (Baylor College of Medicine)
"Phagocytic receptor CED-1 initiates a phagosome maturation pathway"
10:00 am - 10:10 am  Discussion
10:10 am - 10:40 am  Coffee Break
10:40 am - 11:05 am  Michael Hengartner (University of Zurich, Switzerland)
"Negative regulators of engulfment in C. elegans"
11:05 am - 11:15 am  Discussion
11:15 am - 11:30 am  Marc Freeman (University of Massachusetts)
"Shark, a Draper adaptor"
11:30 am - 11:40 am  Discussion
11:40 am - 11:55 am  Estee Kurant (Rockefeller University)
"Searching for Simu partners in phagocytosis"
11:55 am - 12:05 pm  Discussion
12:05 pm - 12:20 pm  Takayuki Kuraishi (Kanazawa University, Japan)
"Pretaporter, a Draper ligand"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session 2
6:00 pm Dinner
7:30 pm - 9:30 pm The Failure: Diseases Developed from Inefficient Removal of Apoptotic Cells
 Discussion Leader: Chris Gregory (University of Edinburgh)
7:30 pm - 7:55 pm  Reinhard E. Voll (University of Erlangen-Nürnberg, Germany)
"Failure of apoptotic cell clearance in patients with SLE"
7:55 pm - 8:05 pm  Discussion
8:05 pm - 8:30 pm  Alexander Gabibov (Russian Academy of Science)
"Catalytic anti-dsDNA autoantibodies in the clearance of apoptotic remnants"
8:30 pm - 8:40 pm  Discussion
8:40 pm - 8:55 pm  Johan van der Vlag (Nijmegen, Netherlands)
"Apoptotic blebs and apoptosis-modified chromatin: killers of tolerance"
8:55 pm - 9:05 pm  Discussion
9:05 pm - 9:20 pm  Ole Petter Rekvig (University of Tromsö, Norway)
"Anti-nuclear immune response"
9:20 pm - 9:30 pm  Discussion

 

WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Alternatives: The Meaning of Apoptotic Cell Clearance in Physiologic State
 Discussion Leader: Nathalie Franc (University College London)
9:00 am - 9:25 am  Mike Overholtzer (Sloan-Kettering Cancer Center)
"Eaten alive: Modeling entosis in human cancers"
9:25 am - 9:35 am  Discussion
9:35 am - 10:00 am  Nick Baker (Albert Einstein College of Medicine)
"The active role of corpse engulfment pathways during cell competition"
10:00 am - 10:10 am  Discussion 
10:10 am - 10:45 am  Coffee Break
10:45 am - 11:10 am  Silvia Finnemann (Cornell University)
"Diurnal engulfment of photoreceptor cell fragments in the retina"
11:10 am - 11:20 am  Discussion
11:20 am - 11:45 am  Eric Baehrecke (University of Massachusetts)
"Genetic regulation of cell clearance during autophagic cell death"
11:45 am - 11:55 am  Discussion
11:55 am - 12:20 pm  Jason Mercer (ETH Zurich, Switzerland)
"Apoptosis mimicry: virus infection by PS-mediated macropinocytosis"
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session 3
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
 (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pm The Consequences: The Meaning of Apoptotic Cell Clearance in Sub-Physiologic State
 Discussion Leader: Adam Lacy-Hulbert (MIT)
7:30 pm - 7:55 pm  Adam Lacy-Hulbert (MIT)
"Kiss and tell: contact with apoptotic cells and macrophages"
7:55 pm - 8:10 pm  Discussion
8:10 pm - 8:35 pm  Chris Gregory (University of Edinburgh)
"Apoptosis and macrophages: the cancer connection"
8:35 pm - 8:50 pm  Discussion
8:50 pm - 9:15 pm  Ian Dransfield (University of Edinburgh)
"Phagocyte recognition of 'decorated' dead cells"
9:15 pm - 9:30 pm  Discussion

 

THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Effects: Positive and Negative Regulation of Apoptotic Cell Clearance
 Discussion Leader: Kirsten Lauber (University of Tuebingen, Germany)
9:00 am - 9:25 am  Xiaojing Ma (Cornell University)
"Transcription factors activated during phagocytosis of apoptotic cells that regulate cytokine production"
9:25 am - 9:35 am  Discussion
9:35 am - 10:00 am  Kirsten Lauber (University of Tuebingen, Germany)
"Migration to apoptotic 'find-me' signals is mediated via the phagocyte receptor G2A"
10:00 am - 10:10 am  Discussion
10:10 am - 10:30 am  Coffee Break
10:30 am - 10:55 am  Dennis Discher (University of Pennsylvania)
"CD47 inhibition of phagocytosis: species specificity, variants, and cytoskeleton"
10:55 am - 11:05 am  Discussion
11:05 am - 11:30 am  Jerry Levine (University of Illinois)
"Signaling events in phagocytes taking up dead cells"
11:30 am - 11:40 am  Discussion
11:40 am - 11:55 am  Luis E. Munoz (University of Erlangen-Nürnberg, Germany)
"Inflammation by misrouted secondarily necrotic remnants"
11:55 am - 12:05 pm  Discussion
12:05 pm - 12:20 pm  Selected Poster (TBA)
12:20 pm - 12:30 pm  Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session 4
6:00 pm Dinner
7:30 pm - 9:30 pm The Use: Clinical Application of Apoptotic Cell Clearance
 Discussion Leader: Sandra Franz (University of Edinburgh)
7:30 pm - 7:55 pm  James George (University of Alabama at Birmingham)
"Role of CD4+ CD25+ T cells in inhibition of cardiac graft rejection following infusion of photopheresis-treated cells"
7:55 pm - 8:10 pm  Discussion
8:10 pm - 8:35 pm  Scott Marshall (University of Newcastle upon Tyne, UK)
"The potential for selective immune control without generalized immune suppression"
8:35 pm - 8:50 pm  Discussion
8:50 pm - 9:15 pm  Thomas Schwarz (University-Clinic Schleswig-Holstein, Germany)
"Mode of action in photopheresis: update on the role of regulatory T cells"
9:15 pm - 9:30 pm  Discussion

 

FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Depart