행사/교육
Mechanisms Of Epilepsy & Neuronal Synchronization - Dynamics, Development And Dysregulation
- 등록일2010-01-11
- 조회수2746
- 구분 국외
- 행사교육분류 행사
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주관기관
..
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행사장소
Colby College
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행사기간
2010-08-03 ~ 2010-08-13
- 원문링크
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첨부파일
Mechanisms Of Epilepsy & Neuronal Synchronization - Dynamics, Development And Dysregulation
The study of epilepsy entails two major questions. What are the mechanisms underlying seizures, i.e. the pathological synchronous electrical discharges in neuronal networks? How does epileptogenesis occur, i.e. what are the mechanisms through which changes in neural function transform normally functioning circuits into pathological ones? Both questions focus on dynamic properties of neural circuits. The first focuses on short term network dynamics and how seizures arise suddenly (in seconds) from a normal electrical background. The second focuses on maladaptive changes in circuits that occur over a longer period of time (days to years) in response to, for example, genetic defects or injury. Improved understanding of these two issues will lead to enhanced treatment of patients with epilepsy and in new therapies that may ultimately prevent the development of epilepsy following brain injury.
The 2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization will present cutting edge research on the theme of dynamics of circuit function. The issue will be addressed at multiple levels of analysis, from function of single molecules, neurons, microcircuits, brain region and the entire brain. Studies utilizing a variety of modern approaches including neurophysiology, imaging, molecular biology, genetics, developmental neurosciences, and neuroanatomy will be presented. The purpose of this conference is to bring together specialists in these fields to discuss the complex issues that arise in the processes of seizure generation and progression. It is expected that a synthesis of current ideas will result and inform the critical next stage of experimental epilepsy research. Topics to be covered include microcircuit dynamics & emergence of synchrony, inhibitory neuron function and dysfunction, neuroinflammation, circuit homeostasis and short term dynamics, epigenetics & gene regulation, circuit development, neural progenitor cells, occult epileptogenic mechanisms, and epileptic ion channels and synaptic proteins.
In addition to our invited speakers at the main meeting, 8 short talks will be selected from submitted abstracts one to two weeks prior to the start of the meeting.
A list of preliminary session topics and speakers is displayed below (discussion leaders are noted in italics). The detailed program is currently being developed by the Conference Chair and will be available by April 8, 2010. Please check back for updates.
- Microcircuit Dynamics: Emergence of Synchrony
(Kevin Staley / Michael Hauser / Rafa Yuste) - Inhibitory Neurons: Failure to Deliver
(Joseph LoTurco / John Rubenstein / Elizabeth Powell) - Neuroinflammation and Epilepsy
(Uwe Heinemann / Annamaria Vezzani / Daniela Kaufer) - Circuit Homeostasis, Analytical and Experimental approaches in Epilepsy
(Ivan Soltesz / Liset Menendez de la Prida) - Epigenetics, Gene Regulation and microRNAs in Epilepsy
(Amy Brooks Kayal / Hungjun Song / Douglas Coulter) - Circuit Development and Function: Basis for Epileptic Networks
(Istvan Mody) - Stem Cells and Epilepsy
(Frances Jensen / Jack Parent / Linda Overstreet-Wadiche) - Epileptogenesis: Occult and Overt Mechanisms
(Helen Scharfman / Michael Wong / Christophe Bernard / Asla Pitkänen) - Epileptic Ion Channels and Synaptic Protein
(Karen Wilcox / David Bredt / Heinz Beck / Jeff Noebels)