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The 59th Natural Products Gordon research Conference will maintain its emphasis on cutting edge developments in natural products isolation, structure elucidation, synthesis, methods development, and other areas enabled by organic chemistry. As in the past, natural products continue to provide the inspiration for advancing the field of organic chemistry and drive developments in many areas of science. They provide a platform for developing new synthetic strategies and methodology for the synthesis of complex small molecules, provide small molecule tools enabling discovery biology efforts, and inspire medicinal chemistry efforts. This year’s outstanding lineup of speakers are reflecting the diverse and vibrant frontiers of science inspired by natural products, and will deliver lectures in topics on isolation, structure elucidation, synthesis, development of synthetic methods, chemical biology, and medicinal and process chemistry. Continuing a highly successful trend, the speakers were also selected from geographically diverse locations and represent leading scientists from both academia and industry.