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The 2010 GRC on Bioanalytical Sensors will present cutting-edge research in a highly multi-disciplinary atmosphere by leaders in the field. This GRC will serve as a conduit for collegial discussions of unpublished data in biochemistry, biology, chemistry, engineering, medicine, and physics as they apply to the development and application of bioanalytical sensors. This meeting will bring together a diverse group of participants ranging from technologists, who are at the forefront of developing novel sensing strategies, to engineers with cutting-edge integration concepts, to biologists with highly impactful application areas that demand new sensing systems. Research themes that will be discussed in the GRC include: 1) molecular recognition using antibodies, nucleic acid probes and alternative recognition elements, 2) recent advances in optical, electrochemical, and mechanical detection, 3) real-world applications including in vivo sensing, 4) use of nanotechnology to advance the understanding of molecular interactions and its integration into sensor design enabling novel applications, and 5) system integration technologies. Specific topical areas that will be covered include (but are not limited to), single molecule-based probes, intracellular sensing, biomaterials with enhanced optical or electronic properties, nanoparticles, biocompatibility and the biological/non-biological interface, miniaturization and automation, and multiplexed detection in complex matrices.