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The Gordon Research Conference on Lipoprotein Metabolism is one of the long standing conferences in the GRC's 78 year history. The scientific content of our conference has continually evolved since the first meeting and it is traditionally the forum in our discipline for the presentation of high impact leading edge science. The program for the 2010 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a spectrum of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact upon human disease. Basic molecular and cell biological studies, animal models of metabolism, and genetic studies in humans will be presented. The topics include metabolism and clearance of triglyceride-rich lipoproteins; HDL and ABC transporters; cellular sterol trafficking and metabolism; the function of lipoproteins, apolipoproteins, and their receptors in the brain; cellular mechanisms and therapeutic potential related to LDL receptor regulation; lipid droplets and cellular lipid metabolism; therapeutic approaches to improving plasma lipoprotein profile; and hepatic lipid and lipoprotein metabolism. In addition, there will be a special keynote session on Thursday evening featuring two world-renowned National Academy of Science members discussing their work on new discoveries in lipid metabolism. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. Additional Oral Sessions will be selected from among submitted abstracts.