행사/교육
Cellular & Molecular Mechanisms of Toxicity
- 등록일2015-07-06
- 조회수4035
- 구분 국외
- 행사교육분류 행사
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주관기관
Gordon Research Seminar
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행사장소
Proctor Academy Andover, NH
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행사기간
2015-08-08 ~ 2015-08-09
- 원문링크
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첨부파일
Application Deadline
Applications for this meeting must be ted by July 11, 2015. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should their application by May 8, 2015. Please refer to the application instructions in the Meeting Deion section below for more details (if available).
Meeting Deion
Overview
The Gordon Research Seminar on Cellular & Molecular Mechanisms of Toxicity is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and ex new data and cutting edge ideas.
The of this meeting is to provide young scientists with an inviting forum for the ex and discussion of primarily new/unpublished data on mechanistic toxicology. The GRS will highlight recent advancements in the development of complex in vitro models, and their utility in safety assessment and understanding mechanisms of toxicity. The GRS will include a career development session with panelists from industry, government, and academia in order to provide attendees with information regarding CV construction, details of writing an effective cover letter, and an overview of the interview process for each job sector.
Attendees are expected to fully participate in the GRS and present original research, thus all applications must include an abstract. Young scientists are invited to present research on all areas of mechanistic toxicology including investigations utilizing in vitro and in vivo systems, translational studies, computational toxicology, and more. The GRS will include approximately 8 graduate student/postdoc platform presentations, which the Chairs will from the abstracts. All attendees are expected to present their original research by presenting a poster. In order to participate, you must an application by the date indicated in the Application Deadline section above. All applicants are strongly encouraged to an application for the associated Gordon Research Conference occurring August 9-14, 2015.
Application Instructions
The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.
The Chairs will speakers from abstracts ted by May 8, 2015. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must an application by the date indicated in the Application Deadline section above.
Meeting Program
| Saturday | |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Developing and Validating 3D Tissues for Predictive and Mechanistic Toxicology Studies |
| Discussion Leader: Jose Manautou (University of Connecticut, USA) | |
| 3:45 pm - 3:50 pm | Opening Remarks |
| 3:50 pm - 4:05 pm | Lorin Jakubek (Sanofi, USA) "Development of a 3D Rat Primary Hepatocyte Model for Predictive and Investigative Toxicology Screens" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Marguerite Vantangoli (Brown University, USA) "Quantification of Morphological and Molecular Changes Associated with Estrogenic Exposure in 3D MCF-7 Human Breast Microtissues" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Organ-Chip and 3D Microtissue Models as the New Frontier in Toxicity Testing |
| Discussion Leaders: Ruth Roberts (Apconix, United Kingdom) and Alessandro Venosa (Rutgers University, USA) | |
| 7:30 pm - 7:55 pm | John Wikswo (Vanderbilt University, USA) "Application of Organ on a Chip Models to Toxicity Testing" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Sharon Presnell (Organovo, USA) "3D Bioprinted Human Tissues as In Vitro Models of the Tissue Response" |
| 8:25 pm - 8:30 pm | Discussion |
| Complex Tissue Models as a Means to Study Disease and the Chronic Injury Response | |
| 8:30 pm - 8:45 pm | Pranita Kabadi (Brown University, USA) "Visualization of 3-Dimensional Human Lung Microtissues for Assessment of Nanoparticle-Induced Toxicity" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Leah Norona (The Hamner-UNC Institute for Drug Safety Sciences, USA) "Utility of exVive3DTM Human Liver Tissue for the Study of Chronic Liver Injury Leading to Fibrosis" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Peter Loskill (University of California, Berkeley, USA) "Organs-on-a-chip ? Microphysiological platforms as in vitro models of cardiac and adipose tissue" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday | |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mechanistic Insights to Liver Injury |
| Discussion Leaders: Craig Fisher (Takeda Cambridge, USA) and Rhiannon Hardwick (Organovo, Inc, USA) | |
| 9:00 am - 9:15 am | Dwayne Carter (The University of Texas Medical Branch, USA) "Aryl Hydrocarbon Receptor Activation by Cinnabarinic Acid Is Required for Stanniocalcin-2 Mediated Protection Against Alcohol Induced Hepatic Injury" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Brandy Garzel (University of Maryland, Baltimore, USA) "Mechanistic Insight into Metformin-Mediated Repression of the Bile Salt Export Pump (BSEP; ABCB11)" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Natalie Holman (University of North Carolina at Chapel Hill, USA) "Alterations in the Content and Quantity of Exosomes Released by Primary Rat and Human Hepatocytes in Response to Toxicant Exposure: Evidence of a Role in Drug-Induced Liver Injury?" |
| 9:55 am - 10:00 am | Discussion |
| Mentorship Component: Career Development Panel | |
| 10:00 am - 11:00 am | Panel Discussion |
| "Looking Beyond Effective CV Construction: Are You Prepared for the Interview Process?" | |
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| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am | |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Predicting the Toxicologic Response |
| Discussion Leader: Charlene McQueen (U.S. Environmental Protection Agency, USA) | |
| 1:30 pm - 1:45 pm | Ezinne Okoro (Kumamoto University, Japan) "Cytotoxic Effects of Neonicotinoids on Human Trophoblast Cells" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Phillip Wages (University of North Carolina at Chapel Hill, USA) "The Role of Hydrogen Peroxide in the Oxidative Modification of Protein Targets in Human Bronchial Epithelial Cells Exposed to 1,2-Naphthoquinone" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Shaun McCullough (U.S. Environmental Protection Agency, USA) "Transforming In Vitro Susceptibility Modeling at the Air-Liquid Interface: Integrating Cellular Signaling, Genetics, and Epigenetics" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms | |
| 3:00 pm | Seminar Concludes |
...................(계속)
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