The changing scope of scientific inquiry and the astonishing rate of data production in systems biology research drive the development of new types of data-centric cyber infrastructures, which, in turn promotes and fosters data and information sharing among researchers. Journals, funding agencies, and governments correspondingly have developed information standards and sharing policies—all of which, in one way or another, address conducting research in an open-access environment (1, 2, 3). A key hallmark of data- and information-sharing policies is the requirement that scientific inquiry and publications must include the submission of publication-relevant information and materials into public repositories. For the most part, data-sharing policies follow the uniform principle for sharing integral data and materials expeditiously (called UPSIDE) (4). Conversely, when research information is not made publicly available to a global scientific community, a corresponding price is paid in lost opportunities, barriers to innovation and collaboration, and the obvious problem of unknowing repetition of similar work (5).