연구 보고서
publication2005_04.pdf
개요
최근 고령화로 인한 장기질환의 증가와 퇴행성 난치병의 증가는 심각한 사회적 문제로서 이러한 장기기능 회복에 대한 해결책 개발이 시급한 상황
가. 정의 및 개념
1) 형질전환 동물
○ 형질전환 동물(Transgenic animal)이란 인위적으로 외래 유전자를 주입하여 본래의 유전형질이 변화되어진 동물을 말함
○ 형질전환 동물은 가축의 생산성 증대 및 생물의약품을 얻기 위해 사람의 유전자를 동물에 삽입하여 발현시키는 살아있는 단백질 생산 공장으로 활용됨
○ 형질전환기술을 이용한 체세포 핵이식 복제 연구와 장기 이식용 복제 돼지 개발 연구가 현재 활발히 진행되는 분야임
2) 이종장기
○ 장기 이식은 일반적으로 심장, 간, 폐, 신장이식이 보통이며, 이중 특히 신장 이식이 가장 많이 일어나고 있음
○ 인간의 장기 이식은 양적인 문제 및 면역적 문제 등 제한점이 많아, 최근 이종간 장기이식이 새로운 대안으로 대두됨
○ 이종장기(바이오 장기)는 이식과 치료의 목적으로 다른 종에서 생산된 장기로, 생명공학적 기법을 응용한 인공 장기와 이를 활용하는 기술을 포함
○ 이종이식(Xenotransplantation)이란 유전적 변형유무에 관계없이 동물의 살아있는 장기나 조직, 또는 세포를 이종간에 이식하는 것을 말함
○ 이종장기 공급원으로 여러 영장류를 고려할 수 있으나, 장기의 크기가 작고 대량번식이 어려운 등 문제점이 많음
○ 현재 장기의 크기가 인간의 것과 비슷하고 생리학적으로 유사하며 사육기간이 짧고 한번에 새끼를 많이 낳을 수 있으며 무균 사육이 가능한 돼지가 최적의 대상으로 대두됨
목차
1. 기술 개요 ···········································1
가. 정의 및 개념 ···················································1
1) 형질전환 동물 ··················································1
2) 이종장기 ·····················································1
3) 연구 필요성 ··················································2
나. 핵심기술 ·······················································3
2. 서지분석 ············································4
가. 특허분석 ························································4
1) 특허로 살펴본 형질전환동물 및 이종장기 세계 동향 ···············4
2) 특허로 살펴본 형질전환동물 및 이종장기 국내 동향 ···············6
나. 논문분석 ·······················································7
1) 논문으로 살펴본 형질전환동물 및 이종장기 세계 동향 ··············7
2) 논문으로 살펴본 형질전환동물 및 이종장기 국내 동향 ··············9
다. 시장성 분석․관련 산업 동향 ····································10
3. 기술 개발동향 ·····································13
가. 세계동향 ······················································13
1) 총괄 국외기술 발전도 ·········································13
2) 주요 연구자 ·················································14
나. 국내동향 ······················································18
1) 총괄 국내 기술 발전도 ········································18
2) 관련 수행 과제 ···············································19
3) 국내 주요 연구자 ·············································19
4. 국내외 기술수준 비교 ································22
가. 기술수준비교 ···················································22
나. SWOT 분석 ··················································23
5. 기대효과 ··········································24
가. 기술적 효과 ···················································24
나. 경제․산업적 효과 ·············································24
6. 참고 문헌 ·········································25
별첨 1. 형질전환동물 및 이종장기 특허분석
별첨 2. 형질전환동물 및 이종장기 논문분석
지식
동향