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Protein disulfide isomerase in vascular disease
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2013-04-26
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#Protein disulfide# isomerase #vascular disease#혈관질환
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Protein disulfide isomerase in vascular disease
Jaehyung Cho
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL, USA
Thiol isomerases facilitate disulfide bond modification, thereby regulating protein folding in the endoplasmic reticulum (ER). Protein disulfide isomerase (PDI), a prototypic thiol isomerase, has 5 and 21 family members in yeast and mammals, respectively (Benham, 2012). Previous studies with genetic deletion of PDI revealed that the PDI gene is essential for yeast viability, probably due to its critical role during protein synthesis (LaMantia et al., 1991).
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